文章：

揭示人类微生物组与胃癌之间的相互作用：复杂关系与治疗途径综述

Unveiling the Interplay Between the Human Microbiome and Gastric Cancer: A Review of the Complex Relationships and Therapeutic Avenues

原文发布日期：12 January 2025

DOI: 10.3390/cancers17020226

类型: Article

开放获取: 是

英文摘要：

The human microbiota plays a crucial role in maintaining overall health and well-being. The gut microbiota has been implicated in developing and progressing various diseases, including cancer. This review highlights the related mechanisms and the compositions that influence cancer pathogenesis with a highlight on gastric cancer. We provide a comprehensive overview of the mechanisms by which the microbiome influences cancer development, progression, and response to treatment, with a focus on identifying potential biomarkers for early detection, prevention strategies, and novel therapeutic interventions that leverage microbiome modulation. This comprehensive review can guide future research and clinical practices in understanding and harnessing the microbiome to optimize gastric cancer therapies.

摘要翻译： 

人体微生物群在维持整体健康与福祉中扮演着关键角色。肠道微生物群已被证实与多种疾病（包括癌症）的发生发展密切相关。本综述重点探讨了微生物群影响癌症发病机制的相关机理及其组成成分，并以胃癌为主要研究对象。我们系统阐述了微生物群影响癌症发生、发展及治疗反应的作用机制，着重探讨了如何通过微生物群调控识别早期检测的潜在生物标志物、制定预防策略以及开发新型治疗干预手段。本综述可为未来研究和临床实践提供指导，助力深入理解并有效利用微生物群以优化胃癌治疗策略。

原文链接：

Unveiling the Interplay Between the Human Microbiome and Gastric Cancer: A Review of the Complex Relationships and Therapeutic Avenues