文章：

术后辅助治疗对高危早期子宫内膜癌女性生存率的影响：一项队列研究

Impacts of Postoperative Adjuvant Therapies on the Survival of Women with High-Risk Early-Stage Endometrial Cancer: A Cohort Study

原文发布日期：8 January 2025

DOI: 10.3390/cancers17020187

类型: Article

开放获取: 是

英文摘要：

Background/Objectives:The survival outcomes according to postoperative adjuvant therapeutic strategy in women with high-risk early-stage endometrial cancer (EEC) have not been clearly compared. This study examined the impacts of various postoperative adjuvant therapies on the survival of women with high-risk EEC.Methods:Korean Health Insurance Review and Assessment Service data related to Korean cancer registration data were used. The data of 1341 women who met the eligibility criteria for high-risk EEC were selected. The overall survival (OS) after the women had received various postoperative adjuvant therapies was analyzed.Results:The mean age of the women was 58.2 ± 10.3 years, and they were followed up for 5.9 ± 4.0 years. When compared with primary surgery alone, the OS was similar in the women who had received adjuvant external beam radiation therapy (EBRT) ± vaginal brachytherapy (VB), adjuvant VB alone, adjuvant chemotherapy, or adjuvant hormone therapy in combination with primary surgery, but the OS was significantly lower in the women who had received adjuvant chemoradiotherapy combined with primary surgery (HR 3.083; 95% CI 1.311–7.247;p= 0.010). In addition, compared to adjuvant EBRT ± VB, the OS was significantly lower in the group given adjuvant radiotherapy after chemotherapy (HR 11.87; 95% CI 4.595–30.664;p< 0.001), but the OS was similar in the women who had received adjuvant VB alone, adjuvant concurrent chemoradiotherapy, or adjuvant chemotherapy after radiotherapy.Conclusions:Except for adjuvant radiotherapy after chemotherapy, postoperative adjuvant therapies have similar impacts on the survival of women with high-risk EEC.

摘要翻译： 

背景/目的：目前尚未明确比较不同术后辅助治疗策略对高危早期子宫内膜癌（EEC）女性患者生存结局的影响。本研究旨在探讨各种术后辅助治疗对高危EEC女性患者生存的影响。 方法：研究采用韩国健康保险审查与评估服务数据及韩国癌症登记数据。筛选出符合高危EEC标准的1341名女性患者数据，分析其接受不同术后辅助治疗后的总生存期（OS）。 结果：患者平均年龄为58.2±10.3岁，平均随访时间为5.9±4.0年。与单纯接受初次手术相比，接受辅助外照射放疗（EBRT）±阴道近距离放疗（VB）、单纯辅助VB、辅助化疗或辅助激素治疗联合初次手术的患者OS相似，但接受辅助放化疗联合初次手术的患者OS显著降低（HR 3.083；95% CI 1.311–7.247；p=0.010）。此外，与辅助EBRT±VB相比，化疗后辅助放疗组的OS显著降低（HR 11.87；95% CI 4.595–30.664；p<0.001），而接受单纯辅助VB、辅助同步放化疗或放疗后辅助化疗的患者OS相似。 结论：除化疗后辅助放疗外，其他术后辅助治疗对高危EEC女性患者的生存影响相似。

原文链接：

Impacts of Postoperative Adjuvant Therapies on the Survival of Women with High-Risk Early-Stage Endometrial Cancer: A Cohort Study