Background/Objectives: Pediatric cancer survivors are at greater risk of cardiometabolic complications than their peers. This study evaluates the preliminary impact of the VIE (Valorization, Implication, Education) intervention, which integrates nutrition, physical activity, and psychological support, on dietary intake and cardiometabolic health among children and adolescents during cancer treatment. Methods: This comparative study includes pediatric cancer patients recruited to either the VIE intervention group or a control group receiving standard care. Post-treatment data on dietary intake, anthropometric measures, blood pressure, and biochemical parameters were compared between groups and stratified by level of involvement in the nutritional intervention and age at diagnosis (children and adolescents). Results: In the intervention group, 45 participants were included (51.1% male, mean age at evaluation 10.2 ± 4.5 years, mean time since end of treatment of 1.3 ± 0.8 years), and the control group comprised 77 participants (44.2% male, mean age at evaluation 12.0 ± 5.6 years, mean time since end of treatment of 1.4 ± 0.8 years). The intervention group had lower total caloric intake (mean: 1759 ± 513 vs. 1997 ± 669 kcal,p= 0.042) and higher calcium intake (mean: 567 ± 240 vs. 432 ± 197 mg/1000 kcal,p= 0.001). The participants who were highly involved in the nutritional intervention had greater protein-derived energy intake than the controls (mean: 17 ± 5 vs. 15 ± 4%,p= 0.029). While there was a tendency for a lesser proportion of cardiometabolic risk factors in the adolescents from the intervention group, the differences did not reach statistical significance. Conclusions: The VIE intervention improved some specific dietary intakes in the medium term after treatment completion but did not significantly impact cardiometabolic health outcomes. Additional strategies are needed to improve the diet of pediatric cancer patients, and further research is warranted to assess the long-term impact of such interventions.
**背景/目的：** 儿童癌症幸存者发生心脏代谢并发症的风险高于同龄人。本研究旨在评估VIE（价值化、参与、教育）干预措施对癌症治疗期间儿童及青少年膳食摄入和心脏代谢健康的初步影响，该干预整合了营养、体力活动和心理支持。 **方法：** 本比较研究纳入的儿童癌症患者被招募至VIE干预组或接受标准护理的对照组。比较了两组在治疗结束后关于膳食摄入、人体测量指标、血压和生化参数的数据，并按照营养干预参与程度以及诊断时年龄（儿童与青少年）进行分层分析。 **结果：** 干预组纳入45名参与者（男性占51.1%，评估时平均年龄10.2 ± 4.5岁，治疗结束至评估的平均时间为1.3 ± 0.8年），对照组包含77名参与者（男性占44.2%，评估时平均年龄12.0 ± 5.6岁，治疗结束至评估的平均时间为1.4 ± 0.8年）。干预组的总热量摄入较低（均值：1759 ± 513 vs. 1997 ± 669 kcal，p=0.042），而钙摄入量较高（均值：567 ± 240 vs. 432 ± 197 mg/1000 kcal，p=0.001）。高度参与营养干预的参与者，其蛋白质供能比高于对照组（均值：17 ± 5 vs. 15 ± 4%，p=0.029）。尽管干预组青少年中存在心脏代谢风险因素比例较低的趋势，但差异未达到统计学显著性。 **结论：** VIE干预在治疗结束后中期改善了一些特定的膳食摄入，但未对心脏代谢健康结局产生显著影响。需要采取额外策略以改善儿童癌症患者的饮食，并有必要进行进一步研究以评估此类干预措施的长期影响。
肿瘤(癌症)患者之家