Background:Head and neck cancer is a deadly disease with over 500,000 cases annually worldwide. Metastatic head and neck cancer accounts for a large proportion of the mortality associated with this disease. Many advances have been made in our understanding of the mechanisms of metastasis. The application of immunotherapy to locally recurrent or metastatic head and neck cancer has not only improved oncologic outcomes but has also provided valuable insights into the mechanisms of immune evasion and ultimately treatment failure.Objectives: This review paper will review our current understanding of biological mechanisms of treatment failure and metastasis. Published and ongoing clinical trials in the management of metastatic head and neck cancer will also be summarized.Methods: A narrative review was conducted to address the current understanding of the mechanisms of treatment failure and current treatment paradigms in recurrent and metastatic head and neck carcinoma.Conclusions:Our understanding of treatment failure in this disease is rapidly evolving. Immunotherapy represents a valuable new tool in the fight against recurrent and metastatic head and neck squamous cell carcinoma. Integrating patient and tumor specific data via artificial intelligence and deep learning will allow for a precision oncology approach, thereby achieving better prognostication and management of patients with this deadly disease.
背景：头颈部癌症是一种致命性疾病，全球每年新增病例超过50万例。转移性头颈部癌症在该疾病相关死亡率中占很大比例。目前对转移机制的认识已取得诸多进展。免疫疗法在局部复发或转移性头颈部癌症中的应用不仅改善了肿瘤学疗效，还为理解免疫逃逸机制及最终治疗失败的原因提供了宝贵见解。 目的：本综述将探讨当前对治疗失败及转移生物学机制的认识，并总结已发表及正在进行的转移性头颈部癌症治疗临床试验。 方法：通过叙述性综述方法，系统阐述当前对头颈部癌复发及转移治疗失败机制的理解，并分析现有治疗模式。 结论：对该疾病治疗失败机制的认识正在快速发展。免疫疗法已成为对抗复发性和转移性头颈部鳞状细胞癌的重要新工具。通过人工智能和深度学习整合患者与肿瘤特异性数据，将实现精准肿瘤学治疗策略，从而为这一致命性疾病患者提供更精准的预后评估和治疗管理。
肿瘤(癌症)患者之家