Background:Understanding the role of personality traits in shaping treatment outcomes is crucial given the multifaceted challenges posed by brain tumors and the significant adverse impact of radiotherapy (RT) on patients’ well-being.Purpose:This study aimed to provide insights into how personality traits affect psychosocial well-being and quality of life during RT in patients with high-grade malignant brain tumors.Methods:Personality traits in patients with high-grade glioma were assessed using the Eysenck Personality Questionnaire-Revised (EPQ-R). Quality of life was analyzed using EORTC questionnaires: the Questionnaire-Core 30 (QLQ-C30) and the Brain Cancer Module (QLQ-BN20). Patients were evaluated before RT, immediately after 6 weeks of RT, and 3 months post-RT.Results:Neuroticism predicted emotional function only three months post-RT. Extraversion decreased quality of life in global health status (third assessment), role function (second assessment), and emotional function (second and third assessments) but improved cognitive (first assessment) and social function (second assessment). The trait associated with lying was linked to a better quality of life in all domains except physical and cognitive function. Anxiety predicted a lower quality of life in brain tumor patients across all domains at various stages of RT treatment.Conclusions:This study advances our understanding of the psychosocial aspects of brain tumor care by highlighting the influence of personality traits on quality-of-life outcomes during RT. Identifying high-grade glioma patients at greater risk of a diminished quality of life based on personality profiles allows healthcare professionals to tailor interventions to address specific psychosocial needs, ultimately enhancing patient outcomes and holistic care during oncological treatment.
背景：鉴于脑肿瘤带来的多方面挑战以及放射治疗（RT）对患者健康的显著负面影响，理解人格特质在塑造治疗结果中的作用至关重要。 目的：本研究旨在探讨高级别恶性脑肿瘤患者在放疗期间，人格特质如何影响其社会心理健康和生活质量。 方法：采用艾森克人格问卷修订版（EPQ-R）评估高级别胶质瘤患者的人格特质，并使用欧洲癌症研究与治疗组织（EORTC）的生活质量核心问卷（QLQ-C30）和脑癌模块（QLQ-BN20）分析生活质量。患者在放疗前、放疗6周后以及放疗后3个月分别接受评估。 结果：神经质仅在放疗后3个月预测情绪功能。外向性降低了整体健康状况（第三次评估）、角色功能（第二次评估）和情绪功能（第二、三次评估）的生活质量，但改善了认知功能（第一次评估）和社会功能（第二次评估）。与说谎相关的特质在除身体和认知功能外的所有领域均与更好的生活质量相关。焦虑预测了脑肿瘤患者在放疗各阶段所有领域生活质量的降低。 结论：本研究通过强调人格特质对放疗期间生活质量结果的影响，增进了我们对脑肿瘤护理社会心理层面的理解。基于人格特征识别生活质量下降风险较高的高级别胶质瘤患者，有助于医疗专业人员针对特定社会心理需求制定个性化干预措施，从而在肿瘤治疗期间改善患者预后并提升整体护理水平。
肿瘤(癌症)患者之家