文章：

胶质母细胞瘤诊断进展：融合遗传学、无创采样与先进成像技术

Advances in Glioblastoma Diagnosis: Integrating Genetics, Noninvasive Sampling, and Advanced Imaging

原文发布日期：2 January 2025

DOI: 10.3390/cancers17010124

类型: Article

开放获取: 是

英文摘要：

Glioblastoma is the most common primary brain tumor in adult patients, and despite standard-of-care treatment, median survival has remained less than two years. Advances in our understanding of molecular mutations have led to changes in the diagnostic criteria of glioblastoma, with the WHO classification integrating important mutations into the grading system in 2021. We sought to review the basics of the important genetic mutations associated with glioblastoma, including known mechanisms and roles in disease pathogenesis/treatment. We also examined new advances in image processing as well as less invasive and noninvasive diagnostic tools that can aid in the diagnosis and surveillance of those undergoing treatment for glioblastoma. Our review is intended to serve as an overview of the current state-of-the-art in the diagnosis and management of glioblastoma.

摘要翻译： 

胶质母细胞瘤是成人患者中最常见的原发性脑肿瘤，尽管采用标准治疗方案，其中位生存期仍不足两年。随着对分子突变认识的深入，胶质母细胞瘤的诊断标准已发生变化，世界卫生组织在2021年分类标准中将重要突变整合至分级系统。本文旨在综述胶质母细胞瘤相关关键基因突变的基础知识，包括已知的致病机制及其在疾病发生发展/治疗中的作用。同时探讨了影像处理技术的新进展，以及可用于辅助胶质母细胞瘤诊疗监测的微创和无创诊断工具。本综述旨在概述当前胶质母细胞瘤诊断与治疗领域的最新进展。

原文链接：

Advances in Glioblastoma Diagnosis: Integrating Genetics, Noninvasive Sampling, and Advanced Imaging