文章：

胃癌腹膜转移外科治疗策略的演进

Evolution in the Surgical Management of Gastric Cancer Peritoneal Metastases

原文发布日期：31 December 2024

DOI: 10.3390/cancers17010100

类型: Article

开放获取: 是

英文摘要：

Despite therapeutic treatments and the growing utilization of multimodal therapies, gastric cancer (GC) remains a highly aggressive malignancy with high mortality worldwide. Much of the complexity in treating GC is due to the high incidence of peritoneal metastasis (PM), with mean overall survival typically ranging from 4 to 10 months. With current systemic therapy, targeted therapies, and immunotherapies continuing to remain ineffective for GC/PM, there has been a significant growing interest in intraperitoneal (IP) therapies for the treatment of GC/PM. In this review, we summarize the development of PM and evolving treatment strategies for GC/PM. Furthermore, we explore the various advancements and outcomes of IP therapies, including heated intraperitoneal chemotherapy (HIPEC), neoadjuvant HIPEC, and pressurized intraperitoneal aerosolized chemotherapy (PIPAC).

摘要翻译： 

尽管治疗手段不断进步且多模式疗法日益普及，胃癌仍是一种全球范围内死亡率极高的侵袭性恶性肿瘤。胃癌治疗复杂性的主要原因在于腹膜转移的高发生率，患者中位总生存期通常仅为4至10个月。鉴于当前全身性治疗、靶向治疗及免疫疗法对胃癌腹膜转移的疗效持续不佳，腹腔内治疗策略日益受到广泛关注。本文综述了腹膜转移的发展机制及胃癌腹膜转移治疗策略的演变，并深入探讨了腹腔内治疗的最新进展与临床结果，包括腹腔热灌注化疗、新辅助腹腔热灌注化疗以及加压腹腔内气溶胶化疗等治疗模式。

原文链接：

Evolution in the Surgical Management of Gastric Cancer Peritoneal Metastases