文章：

肠道菌群失调对胃肠道癌症发病的影响

Effect of Gut Dysbiosis on Onset of GI Cancers

原文发布日期：30 December 2024

DOI: 10.3390/cancers17010090

类型: Article

开放获取: 是

英文摘要：

Dysbiosis in the gut microbiota plays a significant role in GI cancer development by influencing immune function and disrupting metabolic functions. Dysbiosis can drive carcinogenesis through pathways like immune dysregulation and the release of carcinogenic metabolites, and altered metabolism, genetic instability, and pro-inflammatory signalling, contributing to GI cancer initiation and progression.Helicobacter pyloriinfection and genotoxins released from dysbiosis, lifestyle and dietary habits are other factors that contribute to GI cancer development. Emerging diagnostic and therapeutic approaches show promise in colorectal cancer treatment, including the multitarget faecal immunochemical test (mtFIT), standard FIT, and faecal microbiota transplantation (FMT) combined with PD-1 inhibitors. We used search engine databases like PubMed, Scopus, and Web of Science. This review discusses the role of dysbiosis in GI cancer onset and explores strategies such as FMT, probiotics, and prebiotics to enhance the immune response and improve cancer therapy outcomes.

摘要翻译： 

肠道菌群失调通过影响免疫功能和扰乱代谢功能，在胃肠道癌症发展中起着重要作用。菌群失调可通过免疫失调、致癌代谢物释放、代谢改变、遗传不稳定性及促炎信号传导等途径驱动癌变，从而促进胃肠道癌症的发生与发展。幽门螺杆菌感染、菌群失调释放的基因毒素、生活方式及饮食习惯是导致胃肠道癌症发展的其他因素。新兴诊断和治疗方法在结直肠癌治疗中显示出潜力，包括多靶点粪便免疫化学检测（mtFIT）、标准FIT检测，以及粪便微生物移植（FMT）联合PD-1抑制剂疗法。本研究使用PubMed、Scopus和Web of Science等搜索引擎数据库。本综述探讨了菌群失调在胃肠道癌症发生中的作用，并探索了通过FMT、益生菌和益生元等策略增强免疫反应、改善癌症治疗效果的方法。

原文链接：

Effect of Gut Dysbiosis on Onset of GI Cancers