文章：

自体与异体造血细胞移植或CAR-T疗法患者营养状况演变：一项回顾性观察研究

Evolution of Nutritional Status in Patients Undergoing Autologous and Allogeneic Hematopoietic Cell Transplantation or CAR-T Therapy: A Retrospective Observational Study

原文发布日期：30 December 2024

DOI: 10.3390/cancers17010079

类型: Article

开放获取: 是

英文摘要：

Background/Objectives: Hematopoietic cell transplantation (HCT) is a curative treatment for various hematological diseases but can lead to complications which increase malnutrition risk, particularly in allogeneic transplantation patients. This study evaluates the nutritional status evolution of patients undergoing HCT during hospitalization and follow-up. Methods: This retrospective observational study included 365 patients, divided into two groups: 134 underwent allogeneic HCT, while 231 underwent autologous transplantation or CAR-T therapy. Nutritional status was evaluated using Body Mass Index (BMI), Malnutrition Universal Screening Tool (MUST), and Global Leadership Initiative on Malnutrition (GLIM) criteria at four-time points: hospital admission, discharge, two-week follow-up, and one-month follow-up. Non-relapse-related complications were assessed based on hospital readmissions and reports during follow-up visits. Results: Patients experienced significant nutritional deterioration, with decreases in Body Mass Index (BMI) (p< 0.001) and increases in Malnutrition Universal Screening Tool (MUST) (p< 0.001) and Global Leadership Initiative on Malnutrition (GLIM) scores (p< 0.001), particularly among allogeneic transplant recipients (p= 0.025). Severe malnutrition or high malnutrition risk at discharge correlated with increased hospital readmissions during the follow-up (p= 0.024). Conclusions: The observed decline in nutritional status and its associated complications highlight the necessity of multidisciplinary interventions, such as nutritional prehabilitation programs and nutritional support protocols, to enhance clinical outcomes and reduce complications in HCT patients.

摘要翻译： 

背景/目的：造血细胞移植（HCT）是治疗多种血液系统疾病的有效方法，但可能引发并发症，增加营养不良风险，尤其是在异基因移植患者中。本研究评估了HCT患者住院期间及随访期间营养状况的变化。方法：这项回顾性观察性研究纳入了365例患者，分为两组：134例接受异基因HCT，231例接受自体移植或CAR-T治疗。分别在入院时、出院时、两周随访和一个月随访四个时间点，采用体重指数（BMI）、营养不良通用筛查工具（MUST）和全球营养不良领导倡议（GLIM）标准评估营养状况。非复发相关并发症根据随访期间的再入院情况和报告进行评估。结果：患者营养状况显著恶化，表现为体重指数（BMI）下降（p<0.001），营养不良通用筛查工具（MUST）和全球营养不良领导倡议（GLIM）评分升高（p<0.001），尤其在异基因移植受者中更为明显（p=0.025）。出院时存在严重营养不良或高营养不良风险与随访期间再入院率增加相关（p=0.024）。结论：观察到的营养状况下降及其相关并发症凸显了多学科干预的必要性，如营养预康复计划和营养支持方案，以改善HCT患者的临床结局并减少并发症。

原文链接：

Evolution of Nutritional Status in Patients Undergoing Autologous and Allogeneic Hematopoietic Cell Transplantation or CAR-T Therapy: A Retrospective Observational Study