IL-23R (interleukin-23 receptor), found on the surface of several immune cells, plays a key role in the immune system. Indeed, this process is not limited to the inflammatory response but also plays a role in the adaptive immune response. The binding between IL-23R and its specific ligand, the interleukin 23, initiates a number of specific signals by modulating both properties and behavior of immune cells. In particular, it is critical for the regulation of T helper 17 cells (Th17). Th17s are a subset of T cells involved in autoimmune and inflammatory diseases, as well as in cancer. The clinical relevance of IL-23R is underscored by its association with an elevated susceptibility or diminished vulnerability to a spectrum of diseases, including psoriasis, ankylosing spondylitis, and inflammatory bowel disease (IBD). Evidence has emerged that suggests it may also serve to predict both tumor progression and therapeutic responsiveness. It is noteworthy that the IL-23/IL-23R pathway is emerging as a promising therapeutic target. A number of biologic drugs, such as monoclonal antibodies, are currently developing with the aim of blocking this interaction, thus reducing inflammation. This represents a significant advancement in the field of medicine, offering new hope for pursuing more effective and personalized treatments. Recent studies have also investigated the role of such a pathway in autoimmune diseases, and its potential impact on infections as well as in carcinogenesis. The aim of this review is to focus on the role of IL-23R in immune genetics and its potential for modulating the natural history of neoplastic disease.
白细胞介素23受体（IL-23R）表达于多种免疫细胞表面，在免疫系统中发挥关键作用。该受体不仅参与炎症反应调控，同时也在适应性免疫应答中扮演重要角色。当IL-23R与其特异性配体白细胞介素23结合后，可通过调节免疫细胞特性与功能启动一系列特异性信号传导。该通路对辅助性T细胞17（Th17）的调控尤为重要——这类T细胞亚群参与自身免疫性疾病、炎症性疾病及肿瘤的发生发展。 IL-23R的临床意义体现在其与多种疾病易感性的关联中，包括银屑病、强直性脊柱炎和炎症性肠病（IBD）等。最新证据表明，该受体还可能作为预测肿瘤进展和治疗反应性的生物标志物。值得注意的是，IL-23/IL-23R通路已成为极具潜力的治疗靶点，目前多种生物制剂（如单克隆抗体）正在研发中，旨在阻断该通路相互作用以减轻炎症反应。这标志着医学领域的重要进展，为开发更有效、个性化的治疗方案带来新希望。 近期研究还深入探讨了该通路在自身免疫性疾病中的作用，及其在感染性疾病和肿瘤发生中的潜在影响。本综述旨在系统阐述IL-23R在免疫遗传学中的核心作用，并重点分析其调控肿瘤疾病自然病程的潜在价值。
肿瘤(癌症)患者之家