文章：

磁共振成像中疑似显著前列腺癌病灶的炎症特征分析——它们是前列腺癌的模仿者吗？

Analysis of Inflammatory Features in Suspicious Lesions for Significant Prostate Cancer on Magnetic Resonance Imaging—Are They Mimickers of Prostate Cancer?

原文发布日期：27 December 2024

DOI: 10.3390/cancers17010053

类型: Article

开放获取: 是

英文摘要：

Background. Inflammatory features can mimic PCa in suspicious MRI-lesions. Objectives: To assess the incidence of inflammatory features in targeted biopsies to suspicious lesions. Methods. A prospective analysis was conducted of 531 MRI-suspicious lesions with Prostate Imaging-Reporting and Data System (PI-RADS) scores of 3 to 5 in 364 men suspected of having PCa. Results. The incidence of inflammatory features in the MRI-suspicious lesions without PCa was 69.6%, compared to 48.1% in those with PCa (p< 0.001). Among the suspicious lesions without PCa, the incidence of inflammatory features ranged from 68.6% to 71.2% across the PI-RADS categories (p= 0.870). Mild chronic prostatitis increased with higher PI-RADS scores, while acute prostatitis decreased, and granulomatous prostatitis was exclusively observed in patients with PI-RADS scores of 4 and 5. The incidence of inflammatory features in the lesions with insignificant PCa (grade group 1) was 66.7%, compared to 42.7% in those with significant PCa (grade group 2 to 5;p= 0.027). The detection of inflammatory features in MRI-suspicious lesions was identified as an independent predictor of a lower likelihood of significant PCa detection, with an odds ratio (OR) of 0.326 (95% CI 0.196–0.541). Mild chronic prostatitis was the only type of prostatitis which was an independent predictor of a lower likelihood of significant PCa, with an OR of 0.398 (95% CI 0.268–0.590). Conclusions. These data suggest that inflammatory features may be considered mimickers of significant PCa on MRI.

摘要翻译： 

背景：在可疑的磁共振成像（MRI）病灶中，炎症特征可能模拟前列腺癌（PCa）的表现。目的：评估针对可疑病灶进行靶向活检中炎症特征的发生率。方法：对364名疑似前列腺癌患者中531个前列腺影像报告与数据系统（PI-RADS）评分为3至5分的MRI可疑病灶进行前瞻性分析。结果：在未发现前列腺癌的MRI可疑病灶中，炎症特征的发生率为69.6%，而在发现前列腺癌的病灶中为48.1%（p<0.001）。在未发现前列腺癌的可疑病灶中，不同PI-RADS评分分组的炎症特征发生率在68.6%至71.2%之间（p=0.870）。轻度慢性前列腺炎的发生率随PI-RADS评分升高而增加，而急性前列腺炎发生率下降，肉芽肿性前列腺炎仅见于PI-RADS评分为4和5分的患者。在无临床意义前列腺癌（分级组1）的病灶中，炎症特征发生率为66.7%，而在有临床意义前列腺癌（分级组2至5）的病灶中为42.7%（p=0.027）。MRI可疑病灶中炎症特征的检出被确定为有临床意义前列腺癌检出可能性较低的独立预测因子，比值比（OR）为0.326（95%置信区间0.196–0.541）。轻度慢性前列腺炎是唯一能独立预测有临床意义前列腺癌检出可能性较低的前列腺炎类型，OR值为0.398（95%置信区间0.268–0.590）。结论：这些数据表明，在MRI检查中，炎症特征可能被视为有临床意义前列腺癌的模拟表现。

原文链接：

Analysis of Inflammatory Features in Suspicious Lesions for Significant Prostate Cancer on Magnetic Resonance Imaging—Are They Mimickers of Prostate Cancer?