Background: Hypnosis sedation has recently been used for anesthesia in breast oncologic surgery. Methods: Between January 2017 and October 2019, 284 patients from our Breast Clinic (Cliniques Universitaires Saint-Luc, Université Catholique de Louvain) and from the Jolimont Hospital were prospectively included in an interventional non-randomized study approved by our two local ethics committees and registered on clinicaltrials.gov (NCT03330117). Ninety-three consecutive patients underwent surgery while on general anesthesia (GA group). Ninety-two consecutive patients underwent surgery while on general anesthesia preceded by a hypnorelaxation session (GAVRH group). Ninety-five consecutive patients underwent surgery while exclusively on hypnosis sedation (HYPS group). Clinical parameters (pain score, anxiety and distress score) were measured on days 0, 1 and 8 for all patients. All evaluable patients underwent NLR (neutrophil-to-lymphocyte ratio) and CRP (C-reactive protein) dosage on days 0, 1 and 8. Results: Pain scores and anxiety scores were statistically lower in the HYPS group on days 1 and 8, as was the duration of NSAID consumption. NLR and CRP values were significantly inferior on day 1 for all patients who benefited from hypnosis sedation. Conclusions: Some benefits of hypnosis sedation (reduction in postoperative pain, decrease in NSAID consumption) are correlated with a significant reduction in inflammatory parameters in the perioperative process.
背景：近年来，催眠镇静技术已应用于乳腺肿瘤外科手术的麻醉。方法：2017年1月至2019年10月期间，我们前瞻性纳入来自圣吕克大学医院（天主教鲁汶大学）乳腺门诊及若利蒙医院的284例患者，开展一项经两家机构伦理委员会批准的非随机干预性研究，该研究已在ClinicalTrials.gov注册（编号NCT03330117）。其中93例连续患者接受全身麻醉手术（GA组），92例连续患者在全身麻醉前接受催眠放松治疗（GAVRH组），95例连续患者全程采用纯催眠镇静手术（HYPS组）。所有患者在第0、1、8天接受临床参数（疼痛评分、焦虑与痛苦评分）评估。可评估患者均在第0、1、8天进行中性粒细胞-淋巴细胞比值（NLR）与C反应蛋白（CRP）检测。结果：HYPS组在第1、8天的疼痛评分与焦虑评分显著降低，非甾体抗炎药使用时长亦显著缩短。所有接受催眠镇静的患者在第1天的NLR与CRP值均显著降低。结论：催眠镇静在围手术期带来的临床获益（术后疼痛减轻、非甾体抗炎药用量减少）与炎症指标的显著下降具有相关性。
肿瘤(癌症)患者之家