Skin cancer is one of the most prevalent malignancies in the world, with increasing incidence. In 2022, the World Health Organization estimated over 1.5 million new diagnoses of skin malignancies, primarily affecting the older population. Surgical excision, particularly in the head and neck area, can cause aesthetic deficits and significantly impair patients’ quality of life. There are limited therapeutic options for advanced skin malignancies, and the development of resistance to targeted therapy further restricts treatment choices. Cancer metabolism may offer a novel approach to overcome these challenges. The pentose phosphate pathway, along with its rate-limiting enzyme, glucose-6-phosphate dehydrogenase, is essential for both the antioxidative response and the synthesis of ribonucleotides and may play a critical role in the proliferation and growth of cancer cells. This review examines current knowledge on the correlation between altered glucose-6-phosphate dehydrogenase expression and activity and skin cancer progression, with the aim of identifying a potential therapeutic target for treating advanced skin cancer.
皮肤癌是全球最常见的恶性肿瘤之一，其发病率呈持续上升趋势。2022年世界卫生组织数据显示，全球新增皮肤恶性肿瘤病例超过150万例，该疾病主要累及老年群体。手术切除（尤其是头颈部病灶）可能导致容貌缺损，严重影响患者生活质量。晚期皮肤恶性肿瘤的治疗选择有限，而靶向治疗耐药性的出现进一步制约了临床决策。肿瘤代谢研究或可为突破当前治疗困境提供新思路。磷酸戊糖途径及其限速酶葡萄糖-6-磷酸脱氢酶，在抗氧化反应及核糖核苷酸合成中具有关键作用，可能对癌细胞的增殖生长至关重要。本文综述了葡萄糖-6-磷酸脱氢酶表达与活性改变与皮肤癌进展相关性的现有研究，旨在为晚期皮肤癌治疗探寻潜在治疗靶点。
肿瘤(癌症)患者之家