Introduction:Neuroendocrine tumors are a diverse group of tumors predominantly found in the gastrointestinal tract or respiratory system.Methods: This retrospective study aimed to measure the serum concentrations of LRP6 (low-density lipoprotein receptor-related protein 6), SFRP3 (secreted frizzled-related protein 3), and DVL1 (segment polarity protein dishevelled homolog) using the ELISA method in patients with NETs (N = 80) and a control group (N = 62). We evaluated the results against various demographic, clinicopathological, and biochemical characteristics.Results: Our analyses revealed that the concentration of SFRP3 in patients with neuroendocrine tumors was significantly elevated (p< 0.001) compared to the control group. Additionally, DVL1 concentrations were significantly higher (p< 0.01) in patients with BP-NETs compared to GEP-NETs. Furthermore, DVL1 analysis showed a moderate negative correlation with chromogranin A (p< 0.001) and weak negative correlations with serotonin (p< 0.05) and 5-HIAA (p< 0.05). Significant negative correlations were also observed between DVL1 and age in the control group (p< 0.01), and between LRP6 and Ki-67 in the study group.Conclusions:These results suggest that changes in the SFRP3 and DVL1 pathways play a key role in NET development. Elevated levels of these proteins highlight their importance in tumor biology, with SFRP3 and DVL1 potentially being crucial in NET molecular mechanisms. Further research is needed to explore their roles and potential in diagnosis and treatment.
引言：神经内分泌肿瘤是一组异质性肿瘤，主要发生于胃肠道或呼吸系统。方法：本回顾性研究采用ELISA法检测神经内分泌肿瘤患者（N=80）与对照组（N=62）血清中LRP6（低密度脂蛋白受体相关蛋白6）、SFRP3（分泌型卷曲相关蛋白3）及DVL1（散乱同源蛋白1）的浓度水平，并结合人口统计学特征、临床病理学参数及生化指标进行综合分析。结果：分析显示神经内分泌肿瘤患者血清SFRP3浓度较对照组显著升高（p<0.001）；支气管肺神经内分泌肿瘤患者DVL1水平显著高于胃肠胰神经内分泌肿瘤患者（p<0.01）。DVL1与嗜铬粒蛋白A呈中度负相关（p<0.001），与血清素及5-羟吲哚乙酸呈弱负相关（p<0.05）。对照组中DVL1与年龄呈显著负相关（p<0.01），研究组中LRP6与Ki-67指数呈显著负相关。结论：SFRP3与DVL1信号通路改变在神经内分泌肿瘤发生发展中起关键作用，其表达水平升高凸显了二者在肿瘤生物学中的重要性，提示SFRP3和DVL1可能成为神经内分泌肿瘤分子机制研究的关键靶点，需进一步探索其在诊断与治疗中的潜在价值。
肿瘤(癌症)患者之家