Prostate cancer remains a significant global health concern, with over 1.4 million new cases diagnosed and more than 330,000 deaths each year. The primary clinical challenge that contributes to poor patient outcomes involves the failure to accurately predict and treat at the onset of metastasis, which remains an incurable stage of the disease. This review discusses the emerging paradigm that prostate cancer metastasis is driven by a dysregulation of critical molecular machinery that regulates endosome-lysosome homeostasis. Endosome and lysosome compartments have crucial roles in maintaining normal cellular function but are also involved in many hallmarks of cancer pathogenesis, including inflammation, immune response, nutrient sensing, metabolism, proliferation, signalling, and migration. Here we discuss new insight into how alterations in the complex network of trafficking machinery, responsible for the microtubule-based transport of endosomes and lysosomes, may be involved in prostate cancer progression. A better understanding of endosome-lysosome dynamics may facilitate the discovery of novel strategies to detect and manage prostate cancer metastasis and improve patient outcomes.
前列腺癌仍是全球重大健康问题，每年新增确诊病例超过140万例，死亡病例逾33万例。导致患者预后不良的主要临床挑战在于，当前难以在转移发生初期进行准确预测和治疗，而转移阶段仍是该疾病无法治愈的阶段。本综述探讨了前列腺癌转移的新兴研究范式，即该过程由调控内体-溶酶体稳态的关键分子机制失调所驱动。内体与溶酶体区室在维持正常细胞功能中具有关键作用，同时也参与癌症发病机制的多个特征过程，包括炎症、免疫应答、营养感知、代谢、增殖、信号传导及细胞迁移。本文重点探讨了负责内体与溶酶体微管运输的复杂运输网络发生改变，可能参与前列腺癌进展的新见解。深入理解内体-溶酶体动态机制，或将有助于发现检测和治疗前列腺癌转移的新策略，从而改善患者预后。
肿瘤(癌症)患者之家