Objectives: This study aimed to investigate whether the apparent diffusion coefficient (ADC) maps values of breast lesions presenting as non-mass enhancement (NME) on MRI could predict benign or malignant pathohistological findings. Materials and Methods: This retrospective single-center study included 136 female patients with NME and corresponding ultrasound correlate and a subsequent ultrasound-guided core needle biopsy. The patients were subdivided into benign or malignant subgroups based on pathology reports, which served as the gold standard. Blinded to the pathological results, two radiologists independently measured the ADC values of the depicted NME using punctate, 10 mm and whole tumor regions of interest (ROIs) wherever applicable. The mean of all measurements was also analyzed and compared with the pathologic subdivision. Results: The sensitivity of whole tumor ROI in detecting benign NME is 91% compared to 74% for 10 mm ROI and 78% for punctate ROI. No significant differences in ADC values were observed when comparing fatty breast tissue and dense breast tissue. Conclusions: There were differences in ADC values between benign and malignant findings using all types of measurements, where the whole tumor ROI was the most sensitive.
目的：本研究旨在探讨磁共振成像中表现为非肿块强化的乳腺病灶，其表观扩散系数图数值是否能够预测良性或恶性的病理组织学结果。材料与方法：这项回顾性单中心研究纳入了136例磁共振表现为非肿块强化、超声检查有对应病灶并随后接受超声引导下空心针穿刺活检的女性患者。根据作为金标准的病理报告，患者被细分为良性或恶性亚组。在不知晓病理结果的情况下，两位放射科医生独立测量了所显示非肿块强化的表观扩散系数值，测量时在可行的情况下分别采用点状、10毫米及全肿瘤感兴趣区。所有测量值的平均值也进行了分析，并与病理学细分结果进行比较。结果：在检测良性非肿块强化方面，全肿瘤感兴趣区的敏感性为91%，而10毫米感兴趣区为74%，点状感兴趣区为78%。比较脂肪型乳腺组织与致密型乳腺组织时，未观察到表观扩散系数值存在显著差异。结论：使用所有类型的测量方法，良性与恶性结果之间的表观扩散系数值均存在差异，其中全肿瘤感兴趣区的敏感性最高。
肿瘤(癌症)患者之家