Narrow band imaging (NBI) magnification endoscopy for the diagnosis of early-stage oral cavity-related cancer and precancerous lesions can recognize oral lesions as brownish areas, and can observe intraepithelial papillary capillary loops (IPCLs) in the mucosa and submucosa to make a qualitative diagnosis of the lesion and highlight the mucosal surface microstructure to facilitate appropriate diagnosis and early treatment. IPCLs are classified from Type 0 to IV: Type 0 is normal mucosa or no blood vessels observed, e.g., in keratinization; Type I is mainly normal mucosa; Type II is mainly inflammatory sites or non-malignant lesions; Type III is mainly precancerous or suspected malignant lesions; and Type IV is cancerous or malignant lesions. NBI magnification endoscopy is a useful noninvasive method for identifying the malignant transformation of oral potentially malignant disorders (OPMDs). Oral lesions classified as IPCL Type II or higher are atypical epithelial or oral squamous cell carcinoma (OSCC); oral biopsy is recommended for early and accurate diagnosis, and is an indicator of the appropriate biopsy site in the follow-up for OPMDs. In the future, the accuracy of NBI magnification endoscopy for malignant transformation of OPMDs and OSCC will be further confirmed.
窄带成像放大内镜用于诊断早期口腔相关癌症及癌前病变，可识别口腔病变为褐色区域，并能观察黏膜及黏膜下上皮内乳头样毛细血管袢，从而对病变进行定性诊断，并突显黏膜表面微观结构以利于准确诊断和早期治疗。上皮内乳头样毛细血管袢分为0至IV型：0型为正常黏膜或未见血管，如角化区域；I型主要为正常黏膜；II型主要为炎症部位或非恶性病变；III型主要为癌前病变或可疑恶性病变；IV型为癌性或恶性病变。窄带成像放大内镜是一种有用的无创方法，用于识别口腔潜在恶性疾病的恶性转化。被分类为上皮内乳头样毛细血管袢II型或更高的口腔病变为非典型上皮或口腔鳞状细胞癌；建议进行口腔活检以进行早期准确诊断，并作为口腔潜在恶性疾病随访中适当活检部位的指标。未来，窄带成像放大内镜对口腔潜在恶性疾病恶性转化及口腔鳞状细胞癌的诊断准确性将得到进一步证实。
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