Squamous cell carcinoma is the most common malignancy affecting the sinonasal tract. Local recurrence is the main pattern of treatment failure, affecting nearly half of patients treated for primary sinonasal squamous cell carcinoma (SNSCC). Due to disease rarity and heterogeneity of practices, there are limited guidelines for how to diagnose and care for these patients. This paper reviews current evidence regarding etiology, pathophysiology, diagnosis, prognostic factors, and treatment modalities of recurrent SNSCC (rSNSCC). Currently, salvage surgery offers the only durable approach for eligible patients. These resections often require robust reconstructive options due to prior surgery or radiation. Chemoradiation is offered as an adjuvant or palliative approach when surgery is not a feasible option. Emerging options such as immunotherapy and particle therapy remain an area of ongoing investigation.
鳞状细胞癌是影响鼻窦道最常见的恶性肿瘤。局部复发是治疗失败的主要模式，影响近半数原发性鼻窦鳞状细胞癌患者。由于疾病罕见性及临床实践的异质性，目前关于如何诊断和护理这类患者的指南较为有限。本文综述了复发性鼻窦鳞状细胞癌在病因学、病理生理学、诊断、预后因素及治疗方式等方面的现有证据。目前，挽救性手术为符合条件的患者提供了唯一可能实现长期控制的治疗途径。由于既往手术或放疗的影响，这些切除术通常需要强有力的重建方案。当手术不可行时，放化疗可作为辅助或姑息治疗方案。免疫治疗和粒子治疗等新兴疗法仍是当前持续研究的领域。
Recurrent Sinonasal Squamous Cell Carcinoma: Current Insights and Treatment Advances
肿瘤(癌症)患者之家