文章：

唾液在平衡口腔与全身健康、口腔癌及其他疾病中的作用：一篇叙述性综述

Saliva in Balancing Oral and Systemic Health, Oral Cancer, and Beyond: A Narrative Review

原文发布日期：23 December 2024

DOI: 10.3390/cancers16244276

类型: Article

开放获取: 是

英文摘要：

Saliva plays a multifaceted role in oral health and systemic well-being. It supports digestion, protects oral tissues, maintains a healthy oral microbiome, and facilitates wound healing. Additionally, saliva serves as a diagnostic tool that reflects systemic health and disease/therapeutic states. Furthermore, although saliva shows a protective effect against oral cancer development, once tumor formation occurs, it may be involved in tumor progression and metastasis via exosomes and microRNAs. This review discusses the essential role of saliva; its relationship with the development, progression, and metastasis of head and neck squamous cell carcinoma (HNSCC); liquid biopsy tools for early diagnosis and monitoring of HNSCC; and the potential of exosomes as therapeutic agents.

摘要翻译： 

唾液在口腔健康与全身健康中扮演着多面角色。它不仅参与消化过程、保护口腔组织、维持健康的口腔微生物群，还能促进伤口愈合。此外，唾液作为一种诊断工具，能够反映全身健康状况及疾病/治疗状态。值得注意的是，尽管唾液对口腔癌的发生具有保护作用，但一旦肿瘤形成，它可能通过外泌体和微小核糖核酸参与肿瘤的进展与转移。本文综述了唾液的核心功能，探讨其与头颈部鳞状细胞癌发生、发展及转移的关系，介绍了用于早期诊断和监测该疾病的液体活检技术，并展望了外泌体作为治疗载体的潜力。

原文链接：

Saliva in Balancing Oral and Systemic Health, Oral Cancer, and Beyond: A Narrative Review