Background: Many researchers believe that cardia (CGC) and non-cardia (NCGC) are two different types of tumors, having different features like incidence rate, risk factors, geographical location, and socioeconomic status. This study aims to investigate the causes of death (COD) survival rates among early gastric cancer patients with a focus on differences between CGC and NCGC.Methods: This retrospective study employed SEER*stat software (version 8.3.92) to analyze the SEER 17 plus dataset (2000–2019). Standardized mortality ratios (SMR) were computed. Relative survival and conditional survival post-diagnosis were calculated using R software (version 4.1.0) among the different subgroups.Results: Within the follow-up period, 55.4% (5381) died, predominantly within the initial year post-diagnosis. Esophageal cancer was the leading non-gastric cancer cause in CGC, while miscellaneous tumors dominated in NCGC. The 1-year and 5-year relative survival for CGC patients were 76.4% and 48.9% respectively, while for NCGC were 80.4% and 63.9%. The 3-year conditional survival after 1 year and 5e years of survival for CGC were 68.7% and 88.8%, respectively, while for NCGC were 82.2% and 93.5%, respectively. This means that the longer a person has survived after diagnosis with cancer, the greater the likelihood that person will survive for another 3 years.Conclusions: This study sheds light on the substantial impact of non-cancer COD in GC patients, underscoring the necessity of considering comorbidities in their comprehensive management and follow-up.Impact: This study contributes valuable insights for clinical decision-making and informs future research directions regarding CGC and NCGC.
背景：许多研究者认为贲门癌（CGC）与非贲门癌（NCGC）是两种不同类型的肿瘤，在发病率、危险因素、地理分布及社会经济状况等方面存在差异。本研究旨在探讨早期胃癌患者的死亡原因（COD）及生存率，重点关注贲门癌与非贲门癌之间的差异。 方法：本回顾性研究采用SEER*Stat软件（版本8.3.92）分析SEER 17 plus数据库（2000–2019年）数据，计算标准化死亡比（SMR）。使用R软件（版本4.1.0）对不同亚组患者诊断后的相对生存率及条件生存率进行分析。 结果：在随访期间，55.4%（5381例）患者死亡，其中大部分发生在诊断后第一年内。贲门癌患者最主要的非胃癌死亡原因为食管癌，而非贲门癌患者主要为其他类型肿瘤。贲门癌患者的1年及5年相对生存率分别为76.4%和48.9%，非贲门癌患者则分别为80.4%和63.9%。贲门癌患者生存1年及5年后的3年条件生存率分别为68.7%和88.8%，非贲门癌患者分别为82.2%和93.5%。这表明癌症患者确诊后存活时间越长，其继续存活3年的可能性越大。 结论：本研究揭示了非癌症死亡原因对胃癌患者的显著影响，强调了在综合治疗与随访中需重视合并症管理。 意义：本研究为临床决策提供了重要参考，并为未来贲门癌与非贲门癌的研究方向提供了依据。
肿瘤(癌症)患者之家