Background/Objectives: Medullary thyroid carcinoma (MTC) is a highly aggressive tumor, as it is characterized by a high probability of local recurrence and distant metastases, even after surgical treatment. Early detection of disease recurrence is critical for improving long-term treatment outcomes and overall patient survival. By comparing different radiopharmaceuticals, this analysis aimed to strengthen existing guidelines and help bridge the gap between the recommendations of the ESMO and the ATA, highlighting the importance of PET/CT scanning in the postoperative follow-up of patients with MTC. Methods: This research was carried out using three searchable databases, PubMed, ScienceDirect, and ResearchGate, resulting in 575 bibliographic studies up to the date of 20 June 2024. A meta-analysis of diagnostic accuracy was performed using the software Meta—DiSc, Version: 2.0 (Universidad Complutense, Barcelona, Spain), which led to aggregate assessments and the design of the SROC. Results: A quality assessment of the eligible studies was conducted, and the key findings were summarized. Conclusions: Regardless of methodology, PET/CT scanning exhibits high sensitivity and specificity values in the diagnosis of local recurrence and metastases in surgical patients with medullary thyroid carcinoma. Furthermore, based on a comparative analysis of18F-FDG and GA68-DOTATE, it appears that these misunderstood radiopharmaceuticals are particularly sensitive and reliable for highlighting MTC, and it was found that there were no statistical differences in terms of sensitivity and specificity. Therefore, these two modalities appear to be complementary in monitoring MTC patients.
背景/目的：甲状腺髓样癌（MTC）是一种高度侵袭性肿瘤，其特点在于即使经过手术治疗，局部复发和远处转移的概率仍较高。早期发现疾病复发对于改善长期治疗效果及患者总体生存至关重要。本研究通过比较不同放射性药物，旨在强化现有指南，并帮助弥合欧洲肿瘤内科学会（ESMO）与美国甲状腺协会（ATA）指南之间的差异，突出PET/CT扫描在MTC患者术后随访中的重要性。方法：本研究通过检索PubMed、ScienceDirect和ResearchGate三个数据库，截至2024年6月20日共纳入575篇文献。采用Meta-DiSc软件（2.0版，西班牙巴塞罗那康普顿斯大学）进行诊断准确性荟萃分析，得出汇总评估结果并绘制综合受试者工作特征曲线（SROC）。结果：对符合条件的研究进行了质量评估，并总结了关键发现。结论：无论采用何种方法学，PET/CT扫描在诊断甲状腺髓样癌手术患者的局部复发和转移方面均表现出较高的敏感性和特异性。此外，基于对18F-FDG和GA68-DOTATE的比较分析，这两种常被误解的放射性药物在显像MTC时表现出特别的敏感性和可靠性，且两者在敏感性和特异性方面无统计学差异。因此，这两种显像方式在监测MTC患者中具有互补性。
肿瘤(癌症)患者之家