Background: This study aimed to explore the relationship between different types of skin cancer and factors such as sun exposure and photoprotection measures in a Greek cohort on the island of Crete. Methods: This cross-sectional observational study was conducted in the Dermatology Department of the University Hospital in Heraklion, Crete, between January 2019 and January 2024. The study population included consecutive patients diagnosed with basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and malignant melanoma (MM), as well as healthy controls. The participants completed a self-reported questionnaire covering demographic and clinical data as well as questions about sun exposure and photoprotection habits. Results: A total of 265 skin cancer patients and 106 healthy controls participated in the study: 50.6% of the patients had basal cell carcinoma, 35.1% had squamous cell carcinoma, and 14.3% had malignant melanoma. The cohort comprised 41.5% females and 58.5% males, with a mean age of 73.2 years. As expected, the patients with skin cancer had a lighter skin phototype compared to the healthy controls (p< 0.01). They also reported greater occupational (p< 0.01) and leisure sun exposure (p< 0.01) and a higher median number of vacation weeks spent outdoors before the age of 18 (p= 0.030). Furthermore, the healthy controls were more likely to use sunscreen (p= 0.035) and preferred higher SPF (>50) when they did so (p< 0.01). The healthy controls also reported more frequent use of sunglasses (p< 0.01), brimmed hats (p< 0.01), and long-sleeved clothing (p< 0.01) compared to the skin cancer patients. Conclusion: This is the first study to analyze sun exposure and photoprotection behaviors in patients with nonmelanoma skin cancer (NMSC) and malignant melanoma (MM) in Crete, revealing the key associations and underscoring the need for targeted prevention strategies.
背景：本研究旨在探讨希腊克里特岛人群中不同类型皮肤癌与日晒及光防护措施等因素之间的关系。方法：这项横断面观察性研究于2019年1月至2024年1月在克里特岛伊拉克利翁大学医院皮肤科进行。研究对象包括连续入组的基底细胞癌（BCC）、鳞状细胞癌（SCC）和恶性黑色素瘤（MM）确诊患者以及健康对照者。参与者完成了一份自填问卷，内容涵盖人口统计学和临床数据，以及关于日晒和光防护习惯的问题。结果：共有265名皮肤癌患者和106名健康对照者参与研究：50.6%的患者患有基底细胞癌，35.1%患有鳞状细胞癌，14.3%患有恶性黑色素瘤。队列中女性占41.5%，男性占58.5%，平均年龄73.2岁。与预期一致，皮肤癌患者相比健康对照者皮肤光型更浅（p<0.01）。他们自述的职业性（p<0.01）和休闲性日晒暴露（p<0.01）程度更高，18岁前户外度假周数的中位数也更高（p=0.030）。此外，健康对照者更倾向于使用防晒霜（p=0.035），且使用时更偏好高防晒指数（SPF>50）（p<0.01）。与皮肤癌患者相比，健康对照者还报告更频繁地使用太阳镜（p<0.01）、宽檐帽（p<0.01）和长袖衣物（p<0.01）。结论：这是首项在克里特岛分析非黑色素瘤皮肤癌（NMSC）和恶性黑色素瘤（MM）患者日晒暴露与光防护行为的研究，揭示了关键关联性，并强调了制定针对性预防策略的必要性。
肿瘤(癌症)患者之家