Background: Vitamin D deficiency is increasingly recognized as a global health concern, with potential implications for cancer development and progression. This systematic review investigated the prevalence of vitamin D deficiency in pediatric cancer patients and its potential impact on clinical outcomes.Methods: A comprehensive literature search was conducted across multiple databases, including PubMed, Web of Science, and Cochrane Library, to identify the relevant studies published between 2009 and July 2024. Studies were included if they assessed vitamin D status in pediatric cancer patients and reported on the clinical outcomes. Data extraction and quality assessment were performed independently by two reviewers.Results: The review included 20 original articles encompassing a diverse pediatric population with various cancer types. A high prevalence of vitamin D deficiency was observed across the studies. Deficiency was associated with older age and lower socioeconomic status. Several studies reported associations between vitamin D deficiency and the increased risk of infection, poorer treatment response, and decreased survival.Conclusions: Vitamin D deficiency is highly prevalent in pediatric cancer patients and may negatively impact clinical outcomes. Routine screening for vitamin D deficiency and personalized supplementation strategies should be considered in this population. Further research is needed to establish optimal vitamin D management protocols and evaluate the long-term benefits of vitamin D repletion in pediatric oncology.
背景：维生素D缺乏日益被视为全球性健康问题，其对癌症发生与进展的潜在影响备受关注。本系统综述旨在探究儿童癌症患者中维生素D缺乏的患病率及其对临床结局的潜在影响。 方法：通过PubMed、Web of Science及Cochrane Library等多个数据库对2009年至2024年7月期间发表的相关文献进行全面检索。纳入标准为评估儿童癌症患者维生素D状态并报告临床结局的研究。由两名评审员独立完成数据提取与质量评估。 结果：本综述共纳入20篇原创性研究，涵盖多种癌症类型的儿童群体。各研究均显示维生素D缺乏患病率较高，且缺乏状态与年龄增长及社会经济地位较低相关。多项研究报道维生素D缺乏与感染风险增加、治疗反应较差及生存率降低存在关联。 结论：维生素D缺乏在儿童癌症患者中普遍存在，并可能对临床结局产生负面影响。建议对该人群进行常规维生素D筛查并制定个体化补充策略。未来需进一步研究以建立优化的维生素D管理方案，并评估维生素D补充在儿童肿瘤学中的长期获益。
Are Pediatric Cancer Patients a Risk Group for Vitamin D Deficiency? A Systematic Review
肿瘤(癌症)患者之家