Gastric cancer (GC) is a malignant tumor of the gastrointestinal tract associated with high mortality rates and accounting for approximately 1 million new cases diagnosed annually. Surgery, particularly radical gastrectomy, remains the primary treatment; however, there are currently no specific approaches to better distinguish malignant from healthy tissue or to differentiate between metastatic and non-metastatic lymph nodes. As a result, surgeons have to remove all lymph nodes indiscriminately, increasing intraoperative risks for patients and prolonging hospital stay. Near-infrared fluorescence imaging with indocyanine green (ICG) can provide real-time visualization of the surgical field using both conventional laparoscopy and robotic mini-invasive precision surgery platforms. However, its application shows some limits, as ICG is a non-targeted contrast agent. Several studies are now investigating the potential efficacy of fluorescent targeted agents that could selectively bind to the tumor tissue, offering a valuable tool for metastatic mapping during robotic gastrectomy. This review aims to summarize the key fluorescent agents that have been developed to recognize GC markers, as well as those targeting the tumor microenvironment (TME) and metabolic features. These agents hold great potential as valuable tools for enhancing precision surgery in robotic gastrectomy procedures improving the clinical recovery of GC patients.
胃癌是一种消化道恶性肿瘤，死亡率高，每年新发病例约100万例。手术，特别是根治性胃切除术，仍是主要治疗手段；然而，目前尚无特异性方法能更好地区分恶性与健康组织，或鉴别转移性与非转移性淋巴结。因此，外科医生不得不无差别地切除所有淋巴结，这增加了患者的术中风险并延长了住院时间。吲哚菁绿近红外荧光成像技术可通过传统腹腔镜和机器人微创精准手术平台实现手术区域的实时可视化。但其应用存在一定局限性，因为吲哚菁绿是一种非靶向造影剂。目前多项研究正在探索荧光靶向剂的潜在功效，这类制剂能选择性结合肿瘤组织，为机器人胃切除术中的转移灶定位提供重要工具。本综述旨在总结已开发的识别胃癌标志物的关键荧光制剂，以及靶向肿瘤微环境和代谢特征的制剂。这些制剂作为提升机器人胃切除术精准度的有效工具具有巨大潜力，有助于改善胃癌患者的临床康复。
Potential Probes for Targeted Intraoperative Fluorescence Imaging in Gastric Cancer
肿瘤(癌症)患者之家