Despite the introduction of effective systemic therapies and advancements in precision medicine, recurrence or progression remains common in advanced non-small cell lung cancer (NSCLC). For a subset of patients with more localized metastatic disease—referred to as oligometastases and oligo-recurrence—emerging evidence suggests that a multimodal approach combining systemic therapy with local ablative therapies (LATs) may offer curative potential. Oligo-recurrence is defined by the presence of a limited number of metastases and recurrences in patients with controlled primary lesions. In this review, we focus on providing a comprehensive overview of the evidence supporting the concepts of oligo-recurrence in lung cancer, which is considered one of the most curable states among advanced diseases. Although the definition remains variable and is still under discussion, retrospective studies have reported that it is not a rare condition (occurring in 18–53% of cases) and shows relatively better survival outcomes regardless of whether a local ablative therapy (LAT) is performed. However, this classification remains a topic of ongoing debate and warrants further exploration. In addition to an ongoing randomized clinical trial on oligo-recurrent NSCLC, further rigorous studies specifically addressing oligo-recurrence are needed to refine treatment strategies for this advanced yet potentially curable state. These investigations are essential for developing effective, tailored approaches to optimize outcomes for patients within this prognostically favorable subgroup.
尽管已引入有效的全身疗法并实现了精准医学的进步，晚期非小细胞肺癌（NSCLC）的复发或进展仍较为常见。对于部分转移灶较为局限的患者——即寡转移与寡复发——新证据表明，全身治疗联合局部消融治疗（LAT）的多模式疗法可能具有根治潜力。寡复发的定义为原发性病灶受控的患者出现数量有限的转移和复发。本综述旨在全面梳理支持肺癌寡复发概念的相关证据，该状态被视为晚期疾病中最具治愈潜力的情形之一。尽管其定义尚存争议且仍在讨论中，回顾性研究显示该现象并不罕见（发生率约18%-53%），且无论是否实施局部消融治疗，患者均表现出相对更好的生存结局。然而这一分类标准仍是当前争议焦点，亟待进一步探索。除正在进行的寡复发性NSCLC随机临床试验外，仍需开展针对寡复发的严谨研究以完善这一晚期但潜在可治愈状态的治疗策略。这些研究对于制定有效个体化方案、优化该预后良好亚组患者的临床结局至关重要。
Oligo-Recurrence in Lung Cancer; The Most Curable State Among Advanced Disease?
肿瘤(癌症)患者之家