Background/Objectives: This study investigates which demographic, clinical and pathological factors of women with early-stage presurgical EC could be considered risk factors for the presence of different subtypes of metastases in sentinel lymph nodes (SLNs).Methods: This is a retrospective single-center study that collected data between December 2015 and April 2024. EC patients who underwent total hysterectomy with salpingo-oophorectomy and SLN mapping with indocyanine green (ICG) were recorded.Results: Data from 98 women with EC were analyzed. The endometrioid histotype was present in 85 (86%) women, and the non-endometrioid histotype was present in 13 (13%) women. High-grade EC (G3) was present in 21 (21.4%) patients, and low-grade EC (G1-G2) was present in 77 (78.6%) patients. The total number of women with SLN metastasis was 21/98 (21%). Of 21 women, 5 had MAC, 6 had MIC and 10 had ITCs.Conclusions: Preliminary analysis identified three risk factors for nodal involvement: age greater than 67 years, high-grade endometrial carcinomas and myometrial invasion greater than or equal to 50%. Lymphovascular space invasion, histotype 2 and p53 mutation showed a slight, but not statistically significant, tendency to be risk factors for SLN positivity. A deeper analysis with univariate uninominal logistic regression showed that high-grade EC is related to a greater probability of MACs, as shown in other studies, and that low-grade EC (grades 1 and 2) had a strong relationship with low-volume metastasis (LVM); further studies are needed to confirm these results.
背景/目的：本研究旨在探讨早期子宫内膜癌（EC）患者术前的人口统计学、临床及病理学因素中，哪些可被视为前哨淋巴结（SLN）不同亚型转移的风险因素。 方法：本研究为一项回顾性单中心研究，收集了2015年12月至2024年4月期间的数据。研究对象为接受全子宫切除加双侧输卵管卵巢切除术，并采用吲哚菁绿（ICG）进行前哨淋巴结定位的子宫内膜癌患者。 结果：共分析了98例子宫内膜癌女性的数据。其中，85例（86%）为子宫内膜样癌，13例（13%）为非子宫内膜样癌。高级别子宫内膜癌（G3）患者21例（21.4%），低级别子宫内膜癌（G1-G2）患者77例（78.6%）。前哨淋巴结转移患者总数为21/98例（21%）。在这21例患者中，5例为宏转移（MAC），6例为微转移（MIC），10例为孤立肿瘤细胞（ITC）。 结论：初步分析确定了三个淋巴结受累的风险因素：年龄大于67岁、高级别子宫内膜癌以及肌层浸润深度≥50%。淋巴血管间隙浸润、2型组织学亚型和p53突变显示出轻微但无统计学显著性的前哨淋巴结阳性风险趋势。通过单变量单名义逻辑回归的深入分析表明，高级别子宫内膜癌与宏转移（MAC）的发生概率更高相关，这与既往研究一致；而低级别子宫内膜癌（G1和G2）则与低体积转移（LVM）密切相关。这些结果尚需进一步研究加以验证。
Evaluation of Different Risk Factors for Metastatic Sentinel Lymph Nodes in Endometrial Cancer
肿瘤(癌症)患者之家