Background/Objectives: The reported incidence of multiple breast cancers varies widely, ranging from 6 to 60%, depending on the definitions used and methods of detection. With advancements in preoperative imaging techniques, such as magnetic resonance imaging, the detection of multiple breast cancers has improved. However, the clinical significance of multiple breast cancers remains controversial, with conflicting results regarding their impact on prognosis. We investigated the association between the number of synchronous ipsilateral T1 breast tumors, overall survival (OS), and breast cancer-specific survival (BCSS).Methods: We retrospectively analyzed 45,881 patients diagnosed with invasive breast cancer who underwent surgery between 2004 and 2016. The patients were categorized based on the number of tumors: one (n= 43,234), two (n= 2241), and three or more (n= 406). The OS and BCSS scores were compared across the groups.Results: There were no significant differences between the one- and two-tumor groups (p= 0.490 andp= 0.650, respectively). However, patients with three or more tumors had significantly lower OS and BCSS rates than those with one or two tumors (p< 0.001 for both comparisons). Multivariate analysis confirmed that the number of tumors (three or more) was an independent risk factor for poor OS and BCSS.Conclusions: Our findings suggest that patients with synchronous ipsilateral T1 breast cancers and three or more tumors may benefit from escalated treatment strategies due to their potentially worse prognosis.
背景/目的：多发性乳腺癌的报道发病率差异很大，从6%到60%不等，具体取决于所使用的定义和检测方法。随着术前影像技术（如磁共振成像）的进步，多发性乳腺癌的检出率有所提高。然而，多发性乳腺癌的临床意义仍存在争议，关于其对预后影响的研究结果相互矛盾。我们研究了同侧同步性T1期乳腺肿瘤的数量与总生存期（OS）和乳腺癌特异性生存期（BCSS）之间的关联。 方法：我们回顾性分析了2004年至2016年间接受手术的45,881例浸润性乳腺癌患者。根据肿瘤数量将患者分为三组：单发肿瘤（n=43,234）、双发肿瘤（n=2,241）以及三个或更多肿瘤（n=406）。比较各组间的OS和BCSS。 结果：单发肿瘤组与双发肿瘤组之间无显著差异（p值分别为0.490和0.650）。然而，具有三个或更多肿瘤的患者，其OS和BCSS率显著低于单发或双发肿瘤患者（两项比较的p值均<0.001）。多变量分析证实，肿瘤数量（三个或更多）是OS和BCSS不良的独立危险因素。 结论：我们的研究结果表明，对于同侧同步性T1期乳腺癌且具有三个或更多肿瘤的患者，由于其预后可能较差，可能受益于升级的治疗策略。
肿瘤(癌症)患者之家