Cancer and stroke are leading causes of global disability and mortality. With improvements in cancer-associated mortality and advancements in treatment of active malignancy, it is more common to encounter patients with ischemic stroke and active malignancy. Evidence suggests that cancer-associated ischemic stroke is a unique subtype of stroke; however, there is limited guidance when considering diagnostic workup, secondary prevention, rehabilitation, and future directions within this population. In this narrative review, we aim to describe the epidemiology, pathophysiological mechanisms, management, and future directions regarding understanding of cancer-associated ischemic stroke.
癌症与脑卒中均为全球范围内致残与致死的主要原因。随着癌症相关死亡率的改善以及活动性恶性肿瘤治疗手段的进步,缺血性脑卒中合并活动性恶性肿瘤的患者日益常见。现有证据表明,癌症相关缺血性脑卒中是一种独特的脑卒中亚型;然而,针对该人群的诊断检查、二级预防、康复治疗及未来研究方向,目前尚缺乏明确的指导。本文通过叙述性综述,旨在阐述癌症相关缺血性脑卒中的流行病学特征、病理生理机制、临床管理策略及未来研究方向。
Epidemiology, Pathophysiology, and Management of Cancer-Associated Ischemic Stroke