Background/Objectives:With regard to excision of pigmented lesions for detection of malignant melanoma (MM), the number needed to treat (NNT) describes the number of melanocytic nevi that need to be biopsied/excised to detect one MM. The aim should be a low NNT.Methods: Single-center data analysis, including dermatohistopathological records of all nevi and MM cases during 2004–2013 at the Department of Dermatology, University Hospital Regensburg (UKR), was performed. We calculated the NNT, correlating it with the patient’s age and referring physician. The MM to MM in situ ratio was calculated to quantify early detection. As a secondary objective, we stratified into a pre- and post-2008 dataset, coinciding with the introduction of statutory skin cancer screening in Germany.Results: The overall NNT of 118,668 pigmented lesions was 17.2. We found a linear decrease in NNT towards older patients (R2= 62%;p< 0.001). The impact of skin cancer screening in 2008 was marked by a reduction in biopsies/excisions, a shift in age distribution, and a decrease in the NNT from 20.3 to 14.7. Office-based dermatologists had an NNT of 22.3, UKR-based dermatologists had an NNT of 8.0, and non-dermatologists had an NNT of 16.5.Conclusions: The age-related decrease in the NNT emphasizes the importance of age stratification for pigmented lesions. The NNT differed between professional settings. The implementation of skin cancer screening in 2008 was associated with a reduced NNT.
背景/目的：针对色素性皮损切除以检测恶性黑色素瘤（MM），需治疗数（NNT）指为发现一例MM所需活检/切除的黑色素细胞痣数量。理想目标应为较低的NNT值。方法：本研究对雷根斯堡大学医院皮肤科2004-2013年间所有痣与MM病例的皮肤组织病理学记录进行单中心数据分析。通过计算NNT值，分析其与患者年龄及转诊医生的相关性，并计算MM与原位MM比例以量化早期检测效果。次要目标是将数据按2008年德国法定皮肤癌筛查实施时间节点分为前后两个阶段进行分层分析。结果：118,668例色素性皮损总体NNT为17.2。研究发现NNT随患者年龄增长呈线性下降趋势（R²=62%；p<0.001）。2008年皮肤癌筛查实施后呈现三大特征：活检/切除数量减少、年龄分布改变、NNT从20.3降至14.7。执业皮肤科医生的NNT为22.3，本院皮肤科医生为8.0，非皮肤科医生为16.5。结论：NNT随年龄下降的趋势凸显了色素性皮损年龄分层的重要性。不同专业背景医生的NNT存在显著差异。2008年推行的皮肤癌筛查与NNT降低具有显著关联性。
肿瘤(癌症)患者之家