Background/Objectives: The tumour microenvironment (TME) plays an important role in the development and progression of cancer and it differs among lymphomas, both with respect to the composition and quantity of specific tumour-infiltrating immune cells (TICs), such as FoxP3+regulatory T cells (Tregs). The role of FoxP3+Tregs in the TME of peripheral T-cell lymphomas (PTCLs) is complex, and their impact on overall survival (OS) remains unclear. Consequently, we aim to evaluate and compare the FoxP3+cell quantity in nodal PTCLs and reactive lymph nodes (LNs), with a focus on investigating their impact on OS. Methods: excisional lymph node (LN) biopsies from 105 nodal PTCLs and 17 reactive LNs are immunohistochemically stained for FoxP3. Visual scoring of FoxP3+cells is performed, and different cut-off values are used to evaluate the impact of FoxP3+cell quantity on OS. Results: FoxP3+cells are present in the TME of all cases, except for four cases where FoxP3+is expressed in lymphoma cells. Lower FoxP3+cell quantities are observed in certain nodal PTCL subtypes compared to reactive LNs. Patients with high FoxP3+cell quantities show improved OS. However, the FoxP3+cell quantity is not confirmed as an independent prognostic biomarker. Conclusions: these findings underscore the promise of FoxP3+cell quantities as added value in prognosis and highlight the potential benefits of Treg-stimulating therapies in PTCLs.
背景/目的：肿瘤微环境（TME）在癌症的发生发展中起着重要作用，且在不同淋巴瘤中存在差异，这种差异体现在特定肿瘤浸润免疫细胞（如FoxP3+调节性T细胞）的组成和数量上。FoxP3+调节性T细胞在外周T细胞淋巴瘤（PTCLs）肿瘤微环境中的作用复杂，其对总生存期（OS）的影响尚不明确。因此，本研究旨在评估并比较淋巴结PTCLs与反应性淋巴结中FoxP3+细胞数量，重点探究其对总生存期的影响。方法：对105例淋巴结PTCLs和17例反应性淋巴结的切除活检组织进行FoxP3免疫组化染色。通过目视评分法对FoxP3+细胞进行计数，并采用不同截断值评估FoxP3+细胞数量对总生存期的影响。结果：除4例淋巴瘤细胞表达FoxP3+的病例外，所有病例的肿瘤微环境中均存在FoxP3+细胞。与反应性淋巴结相比，某些淋巴结PTCL亚型中FoxP3+细胞数量较低。FoxP3+细胞数量较高的患者总生存期有所改善，但FoxP3+细胞数量尚未被确认为独立的预后生物标志物。结论：这些发现表明FoxP3+细胞数量具有作为预后附加指标的潜力，并凸显了调节性T细胞刺激疗法在PTCL治疗中的潜在益处。
肿瘤(癌症)患者之家