文章：

P53与紫外线辐射诱导的皮肤反应：在触发癌变的黑暗中寻找光明

P53 and the Ultraviolet Radiation-Induced Skin Response: Finding the Light in the Darkness of Triggered Carcinogenesis

原文发布日期：27 November 2024

DOI: 10.3390/cancers16233978

类型: Article

开放获取: 是

英文摘要：

This review delves into the significant cellular and molecular responses triggered by UVR exposure in human skin, emphasizing the pivotal role of mutant p53 (mutp53) in the carcinogenic process elicited by radiation. By underlining the role of a functional p53 in safeguarding skin cells from UVR-induced damage, this work underscores the potential significance of targeting mutp53, aiming to restore its wild-type-like activity (reactivation), as a protective strategy against skin cancer (SC), particularly NMSC. Most importantly, an interesting crosstalk between p53 and its vitamin D receptor (VDR) transcriptional target is also highlighted in the suppression of skin carcinogenesis, which opens the way to promising chemopreventive strategies involving synergistic combinations between mutp53 reactivators and vitamin D. Collectively, this review not only opens new avenues for future research, but also offers promising prospects for the development of novel beneficial approaches in the field of SC.

摘要翻译： 

本综述深入探讨了紫外线辐射（UVR）暴露在人体皮肤中引发的关键细胞与分子反应，重点阐述了突变型p53（mutp53）在辐射诱发癌变过程中的核心作用。通过强调功能性p53在保护皮肤细胞免受UVR损伤中的关键角色，本文指出靶向mutp53以恢复其野生型活性（再激活）作为皮肤癌（SC），特别是非黑色素瘤皮肤癌（NMSC）防护策略的潜在重要意义。尤为重要的是，研究揭示了p53与其维生素D受体（VDR）转录靶点之间在抑制皮肤癌变过程中存在有趣的交互对话，这为开发mutp53再激活剂与维生素D协同作用的化学预防策略开辟了新途径。总体而言，本综述不仅为未来研究开辟了新方向，更为皮肤癌防治领域创新性策略的发展提供了广阔前景。

原文链接：

P53 and the Ultraviolet Radiation-Induced Skin Response: Finding the Light in the Darkness of Triggered Carcinogenesis