文章：

与囊性气腔相关的肺癌：诊断、病理生理学及治疗策略的最新见解

Lung Cancer Associated with Cystic Airspaces: Current Insights into Diagnosis, Pathophysiology, and Treatment Strategies

原文发布日期：24 November 2024

DOI: 10.3390/cancers16233930

类型: Article

开放获取: 是

英文摘要：

Lung cancer associated with cystic airspaces (LCCA) is a rare subtype of non-small-cell lung cancer (NSCLC), accounting for 1–4% of cases. LCCA is characterized by the presence of cystic airspaces within or at the periphery of the tumor on imaging. LCCA poses significant clinical challenges due to its high risk of misdiagnosis or missed diagnosis, often leading to a worse prognosis compared to other forms of lung cancer. While previous studies have identified correlations between the pathological features and imaging characteristics of LCCA, research on its associated driver gene mutations and responses to chemotherapy and immunotherapy remains limited. Furthermore, the development of an appropriate T-staging system is necessary to improve prognostic outcomes. This review provides an overview of the current research on the definition, imaging classification, pathological and molecular mechanisms, and prognosis of LCCA, aiming to provide a reference for clinical decision-making.

摘要翻译： 

囊腔型肺癌是一种罕见的非小细胞肺癌亚型，约占所有病例的1%-4%。其影像学特征表现为肿瘤内部或周边存在囊性气腔。由于该类型肺癌具有较高的误诊及漏诊风险，且相较于其他类型肺癌预后通常更差，给临床诊疗带来显著挑战。既往研究虽已明确其病理特征与影像学表现的相关性，但关于其驱动基因突变特征及对化疗、免疫治疗反应的研究仍较为有限。此外，建立适宜的T分期系统对改善预后评估至关重要。本文综述了当前关于囊腔型肺癌的定义、影像学分型、病理与分子机制及预后的研究进展，旨在为临床诊疗决策提供参考。

原文链接：

Lung Cancer Associated with Cystic Airspaces: Current Insights into Diagnosis, Pathophysiology, and Treatment Strategies