文章：

放射治疗、免疫治疗与化疗在局部晚期或转移性皮肤恶性肿瘤治疗中的作用

The Role of Radiation, Immunotherapy, and Chemotherapy in the Management of Locally Advanced or Metastatic Cutaneous Malignancies

原文发布日期：22 November 2024

DOI: 10.3390/cancers16233920

类型: Article

开放获取: 是

英文摘要：

Introduction: Skin cancer impacts a significant proportion of the population. While surgical management is often the mainstay of treatment, advanced or metastatic cutaneous malignancies require additional local and/or systemic therapies. Methods: A review of the literature was performed studying the use of radiation therapy, chemotherapy, and immunotherapy for locally advanced or metastatic cutaneous malignancies. Results: A summary of the present literature on the management of locally advanced or metastatic cutaneous malignancies is presented across cutaneous head and neck basal cell carcinoma, squamous cell carcinoma, melanoma, and Merkel cell carcinoma. The addition of multidisciplinary therapies to resection is often associated with improved outcomes. Conclusion: The management of cutaneous head and neck malignancies requires an approach integrating multiple specialties, to optimize outcomes and minimize toxicities.

摘要翻译： 

引言：皮肤癌影响着相当一部分人群。虽然手术治疗通常是主要的治疗手段，但对于晚期或转移性皮肤恶性肿瘤，则需要额外的局部和/或全身性治疗。方法：本文通过文献综述，探讨了放射治疗、化学治疗和免疫治疗在局部晚期或转移性皮肤恶性肿瘤中的应用。结果：本文总结了当前关于头颈部皮肤基底细胞癌、鳞状细胞癌、黑色素瘤和默克尔细胞癌等局部晚期或转移性皮肤恶性肿瘤的治疗文献。在切除手术基础上联合多学科治疗通常与改善预后相关。结论：头颈部皮肤恶性肿瘤的治疗需要整合多学科的综合方法，以优化治疗效果并减少毒性反应。

原文链接：

The Role of Radiation, Immunotherapy, and Chemotherapy in the Management of Locally Advanced or Metastatic Cutaneous Malignancies