文章：

热疗肿瘤学中热效应与非热效应的协同作用

The Synergy of Thermal and Non-Thermal Effects in Hyperthermic Oncology

原文发布日期：21 November 2024

DOI: 10.3390/cancers16233908

类型: Article

开放获取: 是

英文摘要：

Background: Modulated electro-hyperthermia (mEHT) is unique due to its combination of thermal and non-thermal effects. Method: This report summarizes the literature on the effects of mEHT observed in vitro and in vivo. Results: The thermal and electrical heterogeneity of tissues allows the radiofrequency signal to selectively target malignant tissue. The applied modulation appears to activate various apoptotic pathways, predominantly leading to immunogenic cell death (ICD). ICD promotes the release of damage-associated molecular patterns, potentially producing tumour-specific antigen-presenting cells. This abscopal-type effect may target distant metastases while treating the primary tumour locally. This immune memory effect is like vaccination mechanisms. Conclusions: The application of mEHT has the potential to expand from local to systemic disease, enabling the simultaneous treatment of micro- and macro-metastases.

摘要翻译： 

背景：调制电热疗法（mEHT）因其兼具热效应与非热效应而具有独特性。方法：本报告综述了关于mEHT在体外及体内效应的相关文献。结果：组织的热学与电学异质性使得射频信号能够选择性靶向恶性组织。所施加的调制作用可激活多种凋亡通路，主要导致免疫原性细胞死亡（ICD）。ICD促进损伤相关分子模式的释放，可能产生肿瘤特异性抗原呈递细胞。这种远隔效应可在局部治疗原发肿瘤的同时靶向远处转移灶。该免疫记忆效应类似于疫苗接种机制。结论：mEHT的应用范围可能从局部疾病扩展至全身性疾病，从而实现对微转移灶和宏观转移灶的同步治疗。

原文链接：

The Synergy of Thermal and Non-Thermal Effects in Hyperthermic Oncology