Glioblastoma (GBM) constitutes the most common primary brain tumor and it remains incurable despite therapeutic advances. The high infiltration/invasion potential of GBM cells is considered to be one of the reasons for the inevitable recurrence of the disease. Radiotherapy (RT) is part of the standard care for patients with GBM, and its benefits on overall survival are extensively reported. However, numerous preclinical studies show that X-ray irradiation can enhance the motility of GBM cells. In the present review, we bring together state-of-the-art research on the impact of radiation on GBM cell motility. The mechanisms through which irradiation impacts the brain tumor microenvironment and the tumor cells themselves, leading to more aggressive/invasive tumors, are described. Finally, we summarize potential pharmacological strategies to overcome this problem. Clinical data validating the occurrence of these processes are urgently needed as they could be of great value for patient outcomes. With this comprehensive review, we expect to highlight the need for methods which allow for monitoring the post-irradiation invasive behavior of GBM in patients.
胶质母细胞瘤（GBM）是最常见的原发性脑肿瘤，尽管治疗手段不断进步，该疾病仍无法治愈。GBM细胞的高浸润/侵袭潜力被认为是该疾病不可避免复发的原因之一。放射治疗（RT）是GBM患者标准治疗方案的一部分，其对总生存期的益处已被广泛报道。然而，大量临床前研究表明，X射线照射可增强GBM细胞的运动能力。本综述汇集了关于辐射对GBM细胞运动能力影响的最新研究进展，阐述了辐射如何影响脑肿瘤微环境及肿瘤细胞自身，从而导致更具侵袭性/浸润性肿瘤的机制。最后，我们总结了克服这一问题的潜在药物策略。亟需验证这些过程发生的临床数据，因其对患者预后可能具有重要价值。通过本综述，我们期望强调开发能够监测患者GBM放疗后侵袭行为的方法的必要性。
Impact of Radiation on Invasion and Migration of Glioma In Vitro and In Vivo
肿瘤(癌症)患者之家