Background/Objectives: T1 relaxation time has been shown to be valuable in detecting and characterizing tumors in various organs. This study aims to determine whether native T1 relaxation time can serve as a useful tool in distinguishing sarcomas from benign tumors.Methods: In this retrospective study, patients with histologically confirmed soft tissue sarcomas and benign tumors were included. Only patients who had not undergone prior treatment or surgery and whose magnetic resonance imaging (MRI) included native T1 mapping were considered. Images were acquired using both 1.5 T and 3 T MRI scanners. T1 histogram parameters were measured in regions of interest encompassing the entire tumor volume, as well as in healthy muscle tissue.Results: Out of 316 cases, 16 sarcoma cases and 9 benign tumor cases were eligible. The T1 values observed in sarcoma did not significantly differ from those in benign lesions in both 1.5 T and 3 T MRIs (p1.5T = 0.260 and p3T = 0.119). However, T1 values were found to be lower in healthy tissues compared to sarcoma at 3 T (p= 0.020), although this difference did not reach statistical significance at 1.5 T (p= 0.063). At both 1.5 T and 3 T, no significant difference between healthy muscle measured in sarcoma cases or benign tumor cases was observed (p1.5T = 0.472 and p3T = 0.226).Conclusions: T1 mapping has the potential to serve as a promising tool for differentiating sarcomas from benign tumors in baseline assessments. However, the standardization of imaging protocols and further improvements in T1 mapping techniques are necessary to fully realize its potential.
背景/目的：T1弛豫时间已被证明在多种器官肿瘤的检测与特征描述中具有重要价值。本研究旨在探讨原生T1弛豫时间能否作为区分肉瘤与良性肿瘤的有效工具。方法：本回顾性研究纳入了经组织学确诊的软组织肉瘤与良性肿瘤患者。仅选取未接受过前期治疗或手术、且磁共振成像包含原生T1 mapping序列的病例。图像采集使用1.5T和3T两种场强的磁共振扫描仪。通过勾画覆盖整个肿瘤体积的感兴趣区域及健康肌肉组织，测量T1直方图参数。结果：在316例病例中，最终纳入16例肉瘤和9例良性肿瘤。在1.5T和3T磁共振中，肉瘤的T1值与良性病变均未呈现显著差异（p1.5T=0.260，p3T=0.119）。然而在3T场强下，健康组织的T1值显著低于肉瘤组织（p=0.020），而1.5T场强下该差异未达统计学意义（p=0.063）。在两种场强下，肉瘤病例与良性肿瘤病例中测量的健康肌肉组织T1值均无显著差异（p1.5T=0.472，p3T=0.226）。结论：T1 mapping技术在基线评估中具有成为区分肉瘤与良性肿瘤的潜力工具。但需通过标准化成像协议及进一步优化T1 mapping技术，方能充分发挥其应用价值。
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