Background/Objectives: Adipophilin (ADP) is a protein associated with lipid droplets, and its expression is related to poor prognosis in certain cancers. However, its impact on the survival of patients with colorectal liver metastases (CRLMs) remains unclear. This study investigated the impact of ADP expression on long-term survival following hepatectomy in patients with CRLM.Methods: We retrospectively analyzed 102 consecutive patients who underwent hepatectomy between 2006 and 2022. ADP expression was examined in resected specimens through immunohistochemical staining using tissue microarrays. Long-term outcomes for ADP-positive (n = 51) and ADP-negative (n = 51) groups were compared with Kaplan–Meier survival analysis.Results: We found significantly decreased 5-year recurrence-free survival (RFS) and overall survival (OS) rates for ADP-positive patients relative to ADP-negative patients (29.4% versus 52.1%, respectively;p= 0.001 and 43.7% versus 72.2%, respectively;p= 0.003). Moreover, multivariate Cox hazards analysis demonstrated that patients with ADP-positive CRLM had a worse prognosis after hepatectomy than those with ADP-negative CRLM, as reflected by both RFS (HR 2.46, 95% CI 1.39–4.36,p= 0.002) and OS (HR: 2.89, 95% CI 1.43–5.85,p= 0.003).Conclusions: ADP expression had a significant prognostic impact on the survival of patients with CRLM following liver resection and may aid in optimal treatment planning.
背景/目的：脂滴相关蛋白（ADP）是一种与脂滴相关的蛋白质，其表达与某些癌症的不良预后相关。然而，其对结直肠癌肝转移（CRLM）患者生存的影响尚不明确。本研究探讨了ADP表达对CRLM患者肝切除术后长期生存的影响。 方法：我们回顾性分析了2006年至2022年间连续接受肝切除术的102例患者。通过组织芯片免疫组化染色检测切除标本中的ADP表达。采用Kaplan-Meier生存分析比较ADP阳性组（n=51）与ADP阴性组（n=51）的长期预后。 结果：与ADP阴性患者相比，ADP阳性患者的5年无复发生存率（RFS）和总生存率（OS）显著降低（分别为29.4%对52.1%，p=0.001；43.7%对72.2%，p=0.003）。此外，多变量Cox风险分析显示，ADP阳性CRLM患者肝切除术后的预后较ADP阴性患者更差，具体体现在RFS（HR 2.46，95% CI 1.39–4.36，p=0.002）和OS（HR: 2.89，95% CI 1.43–5.85，p=0.003）上。 结论：ADP表达对CRLM患者肝切除术后的生存具有显著的预后影响，可能有助于优化治疗计划。
肿瘤(癌症)患者之家