Background/Objectives: Prostate cancer (PCa) is the leading malignancy and the third most common cause of cancer-related death in Argentinian men. Predicting outcomes in localized PCa remains difficult due to tumor heterogeneity. In this study, we assessed the impact ofAR(CAG)nandAPEX1c.444T>G polymorphisms on biochemical relapse in Argentine patients with localized PCa. Methods: We genotyped blood samples from 123 PCa patients forAR(CAG)nandAPEX1p.Asp148Glu (c.444T>G) polymorphisms. Associations with clinicopathological parameters and biochemical relapse-free survival (BRFS) were assessed. Results:AR(CAG)20–23was associated with a family history of breast/ovarian cancer (p= 0.0469). The combination ofAR(CAG)20–23andAPEX1c.444TT/GG correlated with a 2.89 times higher risk of biochemical relapse (log-rankp= 0.006). Multivariable analysis confirmedARandAPEX1polymorphisms as independent predictors of biochemical relapse (HR = 3.95,p= 0.002). In patients with PSA levels <10 ng/mL, combinedAR(CAG)20–23andAPEX1c.444TT/GG genotypes were significantly associated with an increased risk of biochemical relapse (HR = 2.61,p= 0.044). Multivariable analysis confirmed the prognostic significance of these genotypes (HR = 3.44,p= 0.02). Conclusions: This study has identifiedAR(CAG)nandAPEX1c.444T>G polymorphisms as independent predictors of PCa relapse in Argentinian patients, suggesting their potential use in improving prognostic models.
背景/目的：前列腺癌（PCa）是阿根廷男性中最常见的恶性肿瘤，也是癌症相关死亡的第三大原因。由于肿瘤异质性，预测局限性前列腺癌的预后仍然具有挑战性。本研究评估了AR(CAG)n和APEX1 c.444T>G多态性对阿根廷局限性前列腺癌患者生化复发的影响。方法：我们对123例前列腺癌患者的血液样本进行了AR(CAG)n和APEX1 p.Asp148Glu (c.444T>G)多态性基因分型，并评估了其与临床病理参数及无生化复发生存期（BRFS）的关联。结果：AR(CAG)20–23与乳腺癌/卵巢癌家族史相关（p=0.0469）。AR(CAG)20–23与APEX1 c.444TT/GG基因型的组合使生化复发风险增加2.89倍（时序检验p=0.006）。多变量分析证实AR和APEX1多态性是生化复发的独立预测因子（HR=3.95，p=0.002）。在PSA水平<10 ng/mL的患者中，AR(CAG)20–23与APEX1 c.444TT/GG基因型的组合与生化复发风险显著增加相关（HR=2.61，p=0.044）。多变量分析进一步证实了这些基因型的预后意义（HR=3.44，p=0.02）。结论：本研究确定AR(CAG)n和APEX1 c.444T>G多态性是阿根廷前列腺癌患者复发的独立预测因子，表明其具有改善预后模型的潜在应用价值。
肿瘤(癌症)患者之家