Annexin A2 (ANXA2) is a protein that is involved in many physiological and pathological cellular processes. There is compelling evidence that its dysregulated expression, be it up- or downregulation, contributes to the oncogenesis of various neoplasms, including those of the digestive system. The present review summarizes the current knowledge on the role of ANXA2 in the main tumors of the digestive system. The clinical significance of ANXA2 is primordial, due to its potential use as a diagnostic and prognostic biomarker, and as a part of therapeutic protocols. Certain preclinical studies have shown that inhibiting ANXA2 or disrupting its interactions with key molecules can suppress tumor growth, invasion, and metastasis, as well as increase the cancer cells’ sensitivity to treatment in various cancers. Further research is needed to fully elucidate the complex role of ANXA2 in the carcinogenesis of tumors of the digestive system, and to translate these findings into clinical applications for improved diagnosis, prognosis, and treatment.
膜联蛋白A2（ANXA2）是一种参与多种生理及病理性细胞过程的蛋白质。有充分证据表明，其表达失调（无论是上调还是下调）均与多种肿瘤（包括消化系统肿瘤）的发生发展密切相关。本文综述了目前关于ANXA2在消化系统主要肿瘤中作用的研究进展。ANXA2的临床意义至关重要，因其具有作为诊断和预后生物标志物的潜力，并可作为治疗方案的重要组成部分。部分临床前研究表明，抑制ANXA2或阻断其与关键分子的相互作用，能够抑制多种癌症的肿瘤生长、侵袭和转移，并提高癌细胞对治疗的敏感性。未来需要进一步研究以全面阐明ANXA2在消化系统肿瘤发生发展中的复杂作用，并将这些发现转化为临床应用，以改善诊断、预后和治疗效果。
Annexin A2 in Tumors of the Gastrointestinal Tract, Liver, and Pancreas
肿瘤(癌症)患者之家