Background: The aim of this study was to determine the differences in diffusion-weighted imaging (DWI) and dynamic contrast enhancement (DCE) parameters between patients with peritoneal high-grade serous ovarian cancer (HGSOC) recurrence with BRCA mutations (BRCAmut) or BRCA wild type (BRCAwt). Materials and Methods: We retrospectively analyzed the abdominal and pelvic magnetic resonance (MR) images of 43 patients suspected of having recurrent HGSOC, of whom 18 had BRCA1/2 gene mutations. Patients underwent MRI examination via a 1.5 T MRI scanner, and the analyzed parameters were as follows: apparent diffusion coefficient (ADC), time to peak (TTP) and perfusion maximum enhancement (Perf. Max. En.). Results: The mean ADC in patients with BRCAwt was lower than that in patients with BRCAmut: 788.7 (SD: 139.5) vs. 977.3 (SD: 103),p-value = 0.00002. The average TTP value for patients with BRCAwt was greater than that for patients with mutations: 256.3 (SD: 50) vs. 160.6 (SD: 35.5),p-value < 0.01. The Perf. Max. En. value was lower in the BRCAwt group: 148.6 (SD: 12.3) vs. 233.6 (SD: 29.2),p-value < 0.01. Conclusion: Our study revealed a statistically significant correlation between DWI and DCE parameters in examinations of peritoneal metastasis in patients with BRCA1/2 mutations. Adding DCE perfusion to the MRI protocol for ovarian cancer recurrence in patients with BRCAmut may be a valuable tool.
背景：本研究旨在确定携带BRCA基因突变（BRCAmut）或BRCA野生型（BRCAwt）的腹膜高级别浆液性卵巢癌（HGSOC）复发患者之间，扩散加权成像（DWI）与动态对比增强（DCE）参数的差异。材料与方法：我们回顾性分析了43例疑似HGSOC复发患者的腹部及盆腔磁共振（MR）图像，其中18例携带BRCA1/2基因突变。患者通过1.5 T MRI扫描仪接受检查，分析的参数包括：表观扩散系数（ADC）、达峰时间（TTP）及灌注最大强化值（Perf. Max. En.）。结果：BRCAwt患者的平均ADC值低于BRCAmut患者：788.7（标准差：139.5）对比977.3（标准差：103），p值=0.00002。BRCAwt患者的平均TTP值高于突变患者：256.3（标准差：50）对比160.6（标准差：35.5），p值<0.01。BRCAwt组的Perf. Max. En.值较低：148.6（标准差：12.3）对比233.6（标准差：29.2），p值<0.01。结论：我们的研究显示，在BRCA1/2突变患者的腹膜转移检查中，DWI与DCE参数存在统计学显著相关性。在BRCAmut患者的卵巢癌复发MRI检查方案中加入DCE灌注成像，可能是一种有价值的辅助手段。
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