The growth rate of sporadic VS varies considerably, posing challenges for consistent clinical management. This systematic review examines data on factors associated with VS growth, following a protocol registered in the PROSPERO database. The analysis reveals that key predictors of tumor growth include tumor location, initial size, and specific clinical symptoms such as hearing loss and imbalance. Additionally, several studies suggest that growth observed within the first year may serve as an indicator of subsequent progression, enabling the earlier identification of high-risk cases. Emerging factors such as the posture swing test and MRI signal intensity have also been identified as novel predictors that could further refine growth assessments. Our meta-analysis confirms that tumor location, initial size, cystic components, and vestibular symptoms are closely linked to the likelihood of VS growth. This review provides valuable guidance for clinicians in identifying patients who may require closer monitoring or early intervention. By integrating these predictive factors into clinical practice, this review supports more personalized treatment and contributes to the development of more accurate prognostic models for managing untreated sporadic VS.
散发性前庭神经鞘瘤的生长速率存在显著差异，这为临床一致性管理带来了挑战。本系统综述依据PROSPERO数据库注册的研究方案，对与肿瘤生长相关的因素进行了数据分析。研究发现，肿瘤生长的关键预测因素包括肿瘤位置、初始大小以及听力下降和平衡障碍等特定临床症状。此外，多项研究表明，第一年内观察到的生长情况可作为后续进展的指标，有助于早期识别高风险病例。姿势摆动试验和MRI信号强度等新兴因素也被确定为新型预测指标，可进一步完善生长评估。我们的荟萃分析证实，肿瘤位置、初始大小、囊性成分和前庭症状与肿瘤生长可能性密切相关。本综述为临床医生识别需要密切监测或早期干预的患者提供了重要指导。通过将这些预测因素整合到临床实践中，本综述支持更个性化的治疗方案，并有助于建立更精确的未治疗散发性前庭神经鞘瘤预后管理模型。
Untreated Vestibular Schwannoma: Analysis of the Determinants of Growth
肿瘤(癌症)患者之家