Introduction: Radiotherapy is an effective method of treating cancer and affects 50% of patients. Intensity-modulated radiotherapy (IMRT) is a modernized method of classical radiation used in the treatment of laryngeal cancer. Treatment with intent to preserve the larynx is not always safe or complication-free. The microbiome may significantly influence the effectiveness of oncological treatment, especially radiotherapy, and may also be modified by the toxic response to radiation. Objective: The aim of the study was to prospectively assess the microbiome and its influence on radiotherapy toxicity in patients with laryngeal cancer. Results: Statistically significant risk factors for complications after radiotherapy were the percentage of Porphyromonas of at least 6.7%, the percentage of Fusobacterium of at least 2.6% and the percentage of Catonella of at least 2.6%. Conclusions: The importance of the microbiome in oncology has been confirmed in many studies. Effective radiotherapy treatment and the prevention of radiation-induced oral mucositis is a challenge in oncology. The microbiome may be an important part of personalized cancer treatment. The assessment of the microbiome of patients diagnosed with cancer may provide the opportunity to predict the response to treatment and its effectiveness. The influence of the microbiome may be important in predicting the risk group for radiotherapy treatment failure. The possibility of modifying the microbiome may become a goal to improve the prognosis of patients with laryngeal cancer. Fusobacterium, Porphyromonas and Catonella are important risk factors for radiation-induced oral mucositis in patients with laryngeal cancer.
引言：放射治疗是治疗癌症的有效方法，影响50%的患者。调强放射治疗（IMRT）是用于喉癌治疗的经典放射疗法的现代化方法。旨在保留喉部的治疗并非总是安全或无并发症的。微生物组可能显著影响肿瘤治疗（尤其是放射治疗）的效果，并可能因对辐射的毒性反应而发生改变。目的：本研究旨在前瞻性评估喉癌患者的微生物组及其对放射治疗毒性的影响。结果：放射治疗后并发症的统计学显著危险因素包括：卟啉单胞菌比例至少为6.7%、梭杆菌比例至少为2.6%以及卡托内拉菌比例至少为2.6%。结论：微生物组在肿瘤学中的重要性已在多项研究中得到证实。有效的放射治疗及预防放射性口腔黏膜炎是肿瘤学领域的挑战。微生物组可能成为个体化癌症治疗的重要组成部分。对确诊癌症患者的微生物组进行评估，可能为预测治疗反应及其效果提供机会。微生物组的影响对于预测放射治疗失败的风险群体可能具有重要意义。调节微生物组的可能性或将成为改善喉癌患者预后的目标。梭杆菌、卟啉单胞菌和卡托内拉菌是喉癌患者发生放射性口腔黏膜炎的重要危险因素。
肿瘤(癌症)患者之家