Background: Recent research underscores a crucial connection between circadian rhythm disruption and cancer promotion, highlighting an urgent need for attention. Objectives: Explore the molecular mechanisms by which modern lifestyle factors—such as artificial light exposure, shift work, and dietary patterns—affect cortisol/melatonin regulation and cancer risk. Methods: Employing a narrative review approach, we synthesized findings from Scopus, Google Scholar, and PubMed to analyze lifestyle impacts on circadian health, focusing on cortisol and melatonin chronobiology as molecular markers. We included studies that documented quantitative changes in these markers due to modern lifestyle habits, excluding those lacking quantitative data or presenting inconclusive results. Subsequent sections focused solely on articles that quantified the effects of circadian disruption on adipogenesis and tumor microenvironment modifications. Results: This review shows how modern habits lead to molecular changes in cortisol and melatonin, creating adipose microenvironments that support cancer development. These disruptions facilitate immune evasion, chemotherapy resistance, and tumor growth, highlighting the critical roles of cortisol dysregulation and melatonin imbalance. Conclusions: Through the presented findings, we establish a causal link between circadian rhythm dysregulation and the promotion of certain cancer types. By elucidating this relationship, the study emphasizes the importance of addressing lifestyle factors that contribute to circadian misalignment, suggesting that targeted interventions could play a crucial role in mitigating cancer risk and improving overall health outcomes.
背景：近期研究强调了昼夜节律紊乱与癌症发生之间的关键联系，亟需引起重视。目的：探讨现代生活方式因素（如人工光照、轮班工作和饮食模式）影响皮质醇/褪黑素调控及癌症风险的分子机制。方法：采用叙述性综述方法，整合Scopus、Google Scholar和PubMed数据库的研究成果，分析生活方式对昼夜节律健康的影响，重点关注作为分子标志物的皮质醇与褪黑素时间生物学特征。纳入标准为记录现代生活习惯导致这些标志物定量变化的研究，排除缺乏定量数据或结论不明确的研究。后续章节仅聚焦于量化昼夜节律紊乱对脂肪生成及肿瘤微环境改变影响的文献。结果：本综述揭示现代生活习惯如何导致皮质醇与褪黑素的分子水平变化，形成促进癌症发展的脂肪微环境。这些紊乱会助长免疫逃逸、化疗抵抗和肿瘤生长，凸显皮质醇失调与褪黑素失衡的关键作用。结论：通过现有研究发现，我们建立了昼夜节律失调与特定癌症类型发生之间的因果关系。通过阐明这一关联，本研究强调应对导致昼夜节律紊乱的生活方式因素的重要性，指出针对性干预措施可能在降低癌症风险、改善整体健康结局方面发挥关键作用。
Impact of Modern Lifestyle on Circadian Health and Its Contribution to Adipogenesis and Cancer Risk
肿瘤(癌症)患者之家