Background/Objectives: Adenocarcinomas of the esophagogastric junction and stomach present clinical entities with significant cancer-related morbidity and mortality, often requiring multimodal treatments. Preoperative chemotherapy, mainly the FLOT regimen, is increasingly being utilized in the neoadjuvant setting for the treatment of these malignancies, with varying degrees of tumor response.Methods: We conducted a retrospective, single-institution review on 75 patients operated on for adenocarcinoma of the esophagogastric junction and stomach after neoadjuvant FLOT. We investigated whether tumor response correlates with disease response in lymph nodes examined on surgical specimens. We also investigated the role of tumor-infiltrating lymphocytes (TILs) in correlation with primary tumor response and disease response in lymph nodes on pathological specimens.Results: Our results suggest that TILs correlate in a differential manner with regards to primary tumors versus lymph nodes, thus suggesting that there are different biologic processes in place.Conclusions: Our results provide unique evidence on tumor-infiltrating lymphocytes in the adenocarcinoma histology of the esophagogastric junction and stomach and might be important for further studies.
背景/目的：食管胃结合部与胃腺癌是临床中具有显著癌症相关发病率和死亡率的疾病实体，常需多模式治疗。术前化疗，尤其是FLOT方案，越来越多地应用于这些恶性肿瘤的新辅助治疗中，但肿瘤反应程度各异。方法：我们对75例接受新辅助FLOT治疗后行手术治疗的食管胃结合部与胃腺癌患者进行了回顾性单中心研究。我们探讨了手术标本中淋巴结的疾病反应是否与肿瘤反应相关，并研究了肿瘤浸润淋巴细胞（TILs）与原发肿瘤反应及病理标本中淋巴结疾病反应之间的关联。结果：我们的研究结果表明，TILs在原发肿瘤与淋巴结中的关联方式存在差异，提示两者存在不同的生物学过程。结论：本研究为食管胃结合部与胃腺癌组织学中的肿瘤浸润淋巴细胞提供了独特证据，可能对后续研究具有重要意义。
肿瘤(癌症)患者之家