Prostate cancer progression is significantly affected by its tumor microenvironment, in which mesenchymal cells play a crucial role. Stromal cells are modified by cancer mutations, response to androgens, and lineage plasticity, and in turn, engage with epithelial tumor cells via a complex array of signaling pathways and ligand–receptor interactions, ultimately affecting tumor growth, immune interaction, and response to therapy. The metabolic rewiring and interplay in the microenvironment play an additional role in affecting the growth and progression of prostate cancer. Finally, therapeutic strategies and novel clinical trials with agents that target the stromal microenvironment or disrupt the interaction between cellular compartments are described. This review underscores cancer-associated fibroblasts as essential contributors to prostate cancer biology, emphasizing their potential as prognostic indicators and therapeutic targets.
前列腺癌的进展受其肿瘤微环境的显著影响，其中间充质细胞发挥着关键作用。基质细胞通过癌症突变、对雄激素的反应以及谱系可塑性发生改变，进而通过复杂的信号通路和配体-受体相互作用与上皮肿瘤细胞相互作用，最终影响肿瘤生长、免疫反应及治疗应答。微环境中的代谢重编程与相互作用进一步影响前列腺癌的生长与进展。最后，本文综述了针对基质微环境或破坏细胞区室间相互作用的治疗策略及新型临床试验。本综述强调癌症相关成纤维细胞在前列腺癌生物学中的重要作用，并指出其作为预后指标和治疗靶点的潜力。
Deciphering the Tumor Microenvironment in Prostate Cancer: A Focus on the Stromal Component
肿瘤(癌症)患者之家