Background: Metabolic syndrome increases the risk of developing various systemic cancers. The prevalence of metabolic syndrome in newly diagnosed glioblastoma patients is unknown. Further, there have been contradictory reports about how metabolic syndrome affects clinical outcomes. Therefore, the purpose of this study is to test the hypothesis that metabolic syndrome is associated with an increased prevalence of glioblastoma and worsened survival outcomes. Methods: This retrospective cohort study examines seventy-three patients with isocitrate dehydrogenase (IDH)-wild-type glioblastoma as it provides a relatively homogeneous population to examine. Patient characteristics, vital signs, lab results, tumor molecular markers, and overall survival were analyzed. Patients with metabolic syndrome and individual risk factors were identified, and survival outcomes were examined. Results: Our results demonstrate that there is a higher prevalence of metabolic syndrome in our cohort of patients with glioblastoma than in the general population (41% vs. 33%), though this effect is confounded by older age. We also demonstrate that after correction for confounding variables, metabolic syndrome is not significantly associated with overall survival (p= 0.1). When analyzing individual metabolic risk factors, we demonstrate that there is a significant association between the accumulation of metabolic risk factors and decreased survival (p= 0.03), and hyperglycemia emerges as a significant independent risk factor for decreased survival (p= 0.05). Conclusions: These results suggest that metabolic risk factors can affect survival in patients with glioblastoma, which can have significant implications for clinical practice. These findings need to be further explored through further clinical and mechanistic studies.
背景：代谢综合征会增加多种系统性癌症的发病风险。新诊断胶质母细胞瘤患者中代谢综合征的患病率尚不明确。此外，关于代谢综合征如何影响临床结局的报道存在矛盾。因此，本研究旨在验证以下假设：代谢综合征与胶质母细胞瘤患病率升高及生存结局恶化相关。 方法：本回顾性队列研究纳入73例异柠檬酸脱氢酶（IDH）野生型胶质母细胞瘤患者，该人群具有相对同质性，便于分析。研究收集患者临床特征、生命体征、实验室检查结果、肿瘤分子标志物及总生存期数据，识别代谢综合征及个体危险因素患者，并分析其生存结局。 结果：研究显示，虽然年龄因素存在混杂影响，但本队列胶质母细胞瘤患者的代谢综合征患病率高于普通人群（41% vs. 33%）。经混杂变量校正后，代谢综合征与总生存期无显著相关性（p=0.1）。在分析个体代谢危险因素时发现，代谢危险因素的累积与生存期缩短显著相关（p=0.03），其中高血糖是生存期缩短的显著独立危险因素（p=0.05）。 结论：这些结果表明代谢危险因素可能影响胶质母细胞瘤患者的生存期，对临床实践具有重要启示。该发现需通过进一步临床与机制研究深入探索。
Metabolic Risk Factors and Survival in Patients with Glioblastoma
肿瘤(癌症)患者之家