Objectives:This retrospective observational study investigated to determine whether surgery or chemoradiation therapy after induction chemotherapy leads to better swallow function for oropharyngeal cancer patients.Methods:We documented the treatment paths and results of 267 patients with oropharyngeal squamous cell cancer (OPSCC). By quantifying nasogastric (NG) tube usage, surgery after induction chemotherapy (IC–surgery), and chemoradiation therapy after induction chemotherapy (IC-CRT) could be compared to determine the effectiveness of each. Cancer stages were also recorded concerning treatment options. The differences in NG tube usage IC–surgery and IC-CRT groups were compared. The NG tube dependence rates were also presented.Results:The prognosis and tube dependence differed significantly between the two groups. The IC–surgery had a better prognosis compared to IC-CRT for oropharyngeal cancer. The findings indicated that NG tube dependence was greater in advanced tumor stage 4 compared to stages 1–3, and NG tube dependence rates were higher for patients who underwent chemoradiation therapy after induction chemotherapy. Swallowing function was better in the IC–surgery group compared to the IC-CRT group.Conclusions:Higher NG tube retention rates and NG dependence are found in OPSCC patients who choose CRT as their treatment and also in the advanced-stage group.
目的：本回顾性观察研究旨在探讨口咽癌患者在接受诱导化疗后，手术与放化疗两种治疗方式对吞咽功能的影响差异。 方法：研究记录了267例口咽鳞状细胞癌（OPSCC）患者的治疗路径及结果。通过量化鼻饲管使用情况，比较诱导化疗后手术（IC-手术）与诱导化疗后放化疗（IC-CRT）的疗效，并记录不同癌症分期与治疗选择的关系。分析两组患者鼻饲管使用情况的差异，并统计鼻饲管依赖率。 结果：两组患者的预后及鼻饲管依赖率存在显著差异。对于口咽癌患者，IC-手术组的预后优于IC-CRT组。研究显示，晚期肿瘤（4期）患者的鼻饲管依赖率高于1-3期患者，且接受诱导化疗后放化疗的患者鼻饲管依赖率更高。IC-手术组的吞咽功能优于IC-CRT组。 结论：选择放化疗作为治疗方式的OPSCC患者以及晚期肿瘤患者，其鼻饲管留置率及依赖率均较高。
肿瘤(癌症)患者之家