文章：

质子束放射治疗儿童脑干肿瘤后的脑干毒性：一项系统性回顾与荟萃分析

Brainstem Toxicity Following Proton Beam Radiation Therapy in Pediatric Brain Tumors: A Systematic Review and Meta-Analysis

原文发布日期：30 October 2024

DOI: 10.3390/cancers16213655

类型: Article

开放获取: 是

英文摘要：

Background:Proton beam radiation therapy (PBRT) is an advanced cancer treatment modality that utilizes the distinctive physical properties of protons to precisely deliver radiation to tumor targets while sparing healthy tissue. This cannot be obtained with photon radiation. In this systematic review and meta-analysis, we aimed to comprehensively assess the risk of brainstem toxicity in pediatric brain tumor patients undergoing PBRT.Methods:With adherence to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a predetermined search strategy was used to identify eligible articles from PubMed, Web of Science, Scopus, and Cochrane Library through July 2024.Results:The current study included a total of 11 eligible articles. The pooled prevalence of patients who suffered from brainstem toxicity was 1.8% (95% CI: 1%, 2.6%). The pooled prevalences of patients with Grade 1 to Grade 5 brainstem toxicity were found to be 10.6% (95% CI: 8.8%, 30%), 1.5% (95% CI: 0.6%, 2.5%), 0.7% (95% CI: 0.3%, 1.1%), 0.4% (95% CI: 0.1%, 0.7%), and 0.4% (95% CI: 0.1%, 0.8%), respectively, with an overall pooled prevalence of 0.7% (95% CI: 0.4%, 1%).Conclusions:This study revealed a relatively low incidence of symptomatic brainstem toxicity and its related mortality in the pediatric population undergoing PBRT. However, further research is encouraged to study the broader effects of PBRT and to explore various factors that may influence the risk of brainstem toxicity in patients treated with PBRT.

摘要翻译： 

背景：质子束放射治疗（PBRT）是一种先进的癌症治疗方式，它利用质子独特的物理特性，能够精确地将辐射剂量递送至肿瘤靶区，同时保护健康组织，这是光子放射治疗无法实现的。在本系统综述与荟萃分析中，我们旨在全面评估接受PBRT的儿童脑肿瘤患者发生脑干毒性的风险。 方法：遵循系统综述与荟萃分析优先报告条目（PRISMA）指南，采用预设的检索策略，对截至2024年7月的PubMed、Web of Science、Scopus和Cochrane Library数据库中的文献进行检索，以确定符合纳入标准的研究。 结果：本研究共纳入11篇符合条件的文献。汇总分析显示，发生脑干毒性的患者总患病率为1.8%（95% CI：1%， 2.6%）。1级至5级脑干毒性的汇总患病率分别为10.6%（95% CI：8.8%， 30%）、1.5%（95% CI：0.6%， 2.5%）、0.7%（95% CI：0.3%， 1.1%）、0.4%（95% CI：0.1%， 0.7%）和0.4%（95% CI：0.1%， 0.8%），总体汇总患病率为0.7%（95% CI：0.4%， 1%）。 结论：本研究表明，在接受PBRT的儿童患者中，症状性脑干毒性及其相关死亡率的发生率相对较低。然而，鼓励进一步研究以探讨PBRT更广泛的影响，并探索可能影响接受PBRT治疗患者脑干毒性风险的各种因素。

原文链接：

Brainstem Toxicity Following Proton Beam Radiation Therapy in Pediatric Brain Tumors: A Systematic Review and Meta-Analysis