Neurofibromatosis type 1 (NF1) is a genetic disorder that predisposes individuals to develop benign and malignant tumors of the nerve sheath. Understanding the signatures of cancer stem cells (CSCs) for NF1-associated tumors may facilitate the early detection of tumor progression.Background:Neural crest cells, the cell of origin of NF1-associated tumors, can initiate multiple tumor types, including melanoma, neuroblastoma, and schwannoma. CSCs within these tumors have been reported; however, identifying and targeting CSC populations remains a challenge.Results:This study aims to leverage existing studies on neural crest-derived CSCs to explore markers pertinent to NF1 tumorigenesis. By focusing on the molecular and cellular dynamics within these tumors, we summarize CSC signatures in tumor maintenance, progression, and treatment resistance.Conclusion:A review of these signatures in the context of NF1 will provide insights into NF1 tumor biology and pave the way for developing targeted therapies and improving treatment outcomes for NF1 patients.
1型神经纤维瘤病（NF1）是一种遗传性疾病，易使个体发生神经鞘的良性和恶性肿瘤。了解NF1相关肿瘤中癌症干细胞（CSCs）的特征可能有助于早期检测肿瘤进展。 背景： 神经嵴细胞作为NF1相关肿瘤的起源细胞，可引发多种肿瘤类型，包括黑色素瘤、神经母细胞瘤和神经鞘瘤。这些肿瘤中已报道存在CSCs，但识别和靶向CSC群体仍具挑战性。 结果： 本研究旨在利用现有关于神经嵴来源CSCs的研究，探索与NF1肿瘤发生相关的标志物。通过聚焦这些肿瘤内的分子和细胞动态，我们总结了CSCs在肿瘤维持、进展和治疗抵抗中的特征。 结论： 在NF1背景下综述这些特征，将增进对NF1肿瘤生物学的理解，并为开发靶向疗法及改善NF1患者治疗结果铺平道路。
Leveraging Neural Crest-Derived Tumors to Identify NF1 Cancer Stem Cell Signatures
肿瘤(癌症)患者之家