文章：

成纤维细胞生长因子8过表达是食管鳞状细胞癌生存率受损的预测因子，并与ALK/EML4基因改变相关

Overexpression of Fibroblast Growth Factor 8 Is a Predictor of Impaired Survival in Esophageal Squamous Cell Carcinoma and Correlates with ALK/EML4 Alteration

原文发布日期：27 October 2024

DOI: 10.3390/cancers16213624

类型: Article

开放获取: 是

英文摘要：

FGF8, ALK, and EML4 have been identified as promising biomarkers in a number of malignancies. The aim of this study was to examine the prognostic role of FGF8, ALK, and EML4 in esophageal squamous cell carcinoma (ESCC).Methods:Consecutive patients with ESCC who underwent upfront resection were included in this study. ALK and EML4 gene status was evaluated by fluorescence in situ hybridization (FISH) using a triple-color break-apart single-fusion probe and a probe against 2p11. FGF8, ALK, and EML4 protein expression was determined by immunohistochemistry.Results:A total of 122 patients were included in this study. Multivariate analysis revealed that FGF8 overexpression is an independent negative prognostic factor for patients’ overall survival (OS) (p= 0.04). Furthermore, a significant correlation between the expression of FGF8, and ALK (p= 0.04) and EML4 (p= 0.01) alteration was found.Conclusions:FGF8 overexpression is an adverse independent prognostic factor in patients with upfront resected ESCC. Furthermore, FGF8 expression significantly correlates with ALK and EML4 amplification and may therefore qualify as a future therapeutic target.

摘要翻译： 

FGF8、ALK和EML4已被确定为多种恶性肿瘤中具有前景的生物标志物。本研究旨在探讨FGF8、ALK和EML4在食管鳞状细胞癌（ESCC）中的预后作用。 方法：本研究纳入了接受前期切除术的连续ESCC患者。通过荧光原位杂交（FISH）技术，使用三色断裂单融合探针和针对2p11的探针评估ALK和EML4基因状态。采用免疫组织化学方法检测FGF8、ALK和EML4蛋白表达。 结果：本研究共纳入122例患者。多变量分析显示，FGF8过表达是患者总生存期（OS）的独立不良预后因素（p=0.04）。此外，发现FGF8表达与ALK（p=0.04）和EML4（p=0.01）改变之间存在显著相关性。 结论：FGF8过表达是接受前期切除术的ESCC患者的不良独立预后因素。此外，FGF8表达与ALK和EML4扩增显著相关，因此可能成为未来的治疗靶点。

原文链接：

Overexpression of Fibroblast Growth Factor 8 Is a Predictor of Impaired Survival in Esophageal Squamous Cell Carcinoma and Correlates with ALK/EML4 Alteration